Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A physical therapeutic apparatus that has a table-stable base, upon which is mounted a fulcrum pivot point, and an occipital cradle engaged upon the pivot point for selectable and lockable angular motion about the pivot point. The apparatus also has an adjustable chin rest, the chin rest having left and right arms, each arm adjustable for length, each arm adjustably mounted for lateral motion at opposite ends of a pivot point, each arm terminating in releasably connectable ends. An optional dorsal wedge is engaged upon the occipital cradle.

Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a FDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.

Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.

Abstract: A bone anchor delivery system device (10) has a retractable punch driver assembly and a locking mechanism (32). The punch driver assembly has a retractable punch shaft (30) and a guide (20) for receiving the retractable punch shaft (30). The guide (20) is rotatable relative to the punch shaft (30) and the shaft has an extended length with bone penetrating tip (35) at a first end (33). The locking mechanism (32) for locking the retractable punch shaft (30) from linear movement and rotational movement relative to the guide (20) is positioned at an opposite second end. The retractable punch shaft (30) has a reduced diameter end (33) extending from the tip (35) toward a shoulder stop for receiving a releasable punch (12). The releasable punch (12) has a hollow opening for receiving the reduced diameter end (33) of the punch shaft (30). The punch (12) is profiled to pierce and form a bone anchor hole.

Abstract: A bone anchor delivery system device (10) has a retractable punch driver assembly and a locking mechanism (32). The punch driver assembly has a retractable punch shaft (30) and a guide (20) for receiving the retractable punch shaft (30). The guide (20) is rotatable relative to the punch shaft (30) and the shaft has an extended length with bone penetrating tip (35) at a first end (33). The locking mechanism (32) for locking the retractable punch shaft (30) from linear movement and rotational movement relative to the guide (20) is positioned at an opposite second end. The retractable punch shaft (30) has a reduced diameter end (33) extending from the tip (35) toward a shoulder stop for receiving a releasable punch (12). The releasable punch (12) has a hollow opening for receiving the reduced diameter end (33) of the punch shaft (30). The punch (12) is profiled to pierce and form a bone anchor hole.

Abstract: The device (10) has a handle assembly (40) and a bone anchor driver assembly (20). The handle assembly (40) has an upper handle portion (50) and a lower handle portion (60). The upper or lower handle portion is rotatable relative to the other handle portion. A bone anchor driver assembly (20) is for rotatably driving a bone anchor (12) into a hole in a bone. The bone anchor driver assembly (20) is fixed to one of either the upper or lower handle portions (50 or 60).

Abstract: The device (10) has a handle assembly (40) and a bone anchor driver assembly (20). The handle assembly (40) has an upper handle portion (50) and a lower handle portion (60). The upper or lower handle portion is rotatable relative to the other handle portion. A bone anchor driver assembly (20) is for rotatably driving a bone anchor (12) into a hole in a bone. The bone anchor driver assembly (20) is fixed to one of either the upper or lower handle portions (50 or 60).

Abstract: A bone anchor delivery system device (10) has a retractable punch driver assembly and a locking mechanism (32). The punch driver assembly has a retractable punch shaft (30) and a guide (20) for receiving the retractable punch shaft (30). The guide (20) is rotatable relative to the punch shaft (30) and the shaft has an extended length with bone penetrating tip (35) at a first end (33). The locking mechanism (32) for locking the retractable punch shaft (30) from linear movement and rotational movement relative to the guide (20) is positioned at an opposite second end. The retractable punch shaft (30) has a reduced diameter end (33) extending from the tip (35) toward a shoulder stop for receiving a releasable punch (12). The releasable punch (12) has a hollow opening for receiving the reduced diameter end (33) of the punch shaft (30). The punch (12) is profiled to pierce and form a bone anchor hole.

Abstract: The device (10) has a handle assembly (40) and a bone anchor driver assembly (20). The handle assembly (40) has an upper handle portion (50) and a lower handle portion (60) as illustrated. The upper or lower handle portion is rotatable relative to the other handle portion. A bone anchor driver assembly (20) is for rotatably driving a bone anchor (12) into a hole in a bone is provided. The bone anchor driver assembly (20) is fixed to one of either the upper or lower handle portions (50 or 60).

Abstract: A bone anchor delivery system device (10) has a retractable punch driver assembly and a locking mechanism (32). The punch driver assembly has a retractable punch shaft (30) and a guide (20) for receiving the retractable punch shaft (30). The guide (20) is rotatable relative to the punch shaft (30) and the shaft has an extended length with bone penetrating tip (35) at a first end (33). The locking mechanism (32) for locking the retractable punch shaft (30) from linear movement and rotational movement relative to the guide (20) is positioned at an opposite second end. The retractable punch shaft (30) has a reduced diameter end (33) extending from the tip (35) toward a shoulder stop for receiving a releasable punch (12). The releasable punch (12) has a hollow opening for receiving the reduced diameter end (33) of the punch shaft (30). The punch (12) is profiled to pierce and form a bone anchor hole.

Abstract: The device (10) has a handle assembly (40) and a bone anchor driver assembly (20). The handle assembly (40) has an upper handle portion (50) and a lower handle portion (60) as illustrated. The upper or lower handle portion is rotatable relative to the other handle portion. A bone anchor driver assembly (20) is for rotatably driving a bone anchor (12) into a hole in a bone is provided. The bone anchor driver assembly (20) is fixed to one of either the upper or lower handle portions (50 or 60).

Abstract: A camera system for surveillance of a patient's throat is disclosed. The camera system comprises a camera associated with an upper dental arch tray, and does not rest on the patient's tongue. The camera system can optionally include a delivery system for medication, display, and lower dental arch tray. The camera system may be configured as a guide insert in a Rapid Orotracheal Intubation Device.

Abstract: A rapid orotracheal intubation guide device is disclosed that facilitates orotracheal intubation or direct orotracheal visualization without resting the device on the subject's tongue and that, during a bronchoscopic intubation, automatically ejects the endotracheal tube from the device as the endotracheal tube is advanced coaxially over a bronchoscope previous placed through the guide, thereby providing a mid-line entry of the bronchoscope and endotracheal tube, higher intubation success rate by lower skilled operators, and easy removal of the device from the patient's oral cavity.

Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a FDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.

Abstract: A system and method for communicating and validating patient information including medication delivery information in a care-giving facility is provided. A medical transaction carrier is used to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. All information carried by the medical transaction carrier is validated both at the patient specific asset and at the control system. This validation allows for positive control of all transactions even if a medical transaction carrier is lost. The medical transaction carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing and communicating information. The system may use either wired or wireless connections to communicate information between the components of the system.

Abstract: A method, medium and implementing processing system are provided in which the presence of workers in a long highway construction zone is monitored and the electronically-controlled posted speed limit is adjusted in accordance with the detected presence of workers in the immediate area. In an example, Radio Frequency Identification (RFID) scanners or readers are strategically placed in a construction or working area. Such RFID reading devices may be embedded, for example, in construction speed limit signs. The displayed speed limit is controlled by the detected proximity of construction workers wearing RFID-embedded clothing, for example, such as safety vests or helmets. The speed limit sign includes logic to display one of many possible speed limit displays based on the nearest, and/or the number of RFID signals detected in a given area.

Abstract: A system and method for confirming that a medication administration device has been programmed with the correct medication administration parameters. A medical database carrier is used compare medication delivery parameters entered into a medication administration device to institutionally established guidelines or more widely accepted protocols to ensure that the medication is delivered in accordance to those guidelines. The medical database carrier may also be configured to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. The medical database carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing, processing and communicating information.

Abstract: A system and method for confirming that a medication administration device has been programmed with the correct medication administration parameters. A medical database carrier is used compare medication delivery parameters entered into a medication administration device to institutionally established guidelines or more widely accepted protocols to ensure that the medication is delivered in accordance to those guidelines. The medical database carrier may also be configured to communicate information regarding medication delivery and other patient information between a control system in communication with the care-giving facility's other information systems and a patient specific asset such as an infusion pump. The medical database carrier may be a smartcard, a PDA such as a Palm™ Pilot, laptop computer, pager, mobile phone, or other device capable of storing, processing and communicating information.

Abstract: A Meeting Attendee Instant Messaging (MAIM) utility is provided and embeds Instant Messaging (IM) functionality in a calendaring software. When a meeting request is sent out from the calendaring application, the request receives invitee responses, which automatically populates a Meeting Invitee Status Display (MISD). The MISD graphically illustrates which invitees have accepted the request to the meeting (i.e., attendees), and also provides an indication of a current IM status of each attendee to the meeting. The meeting facilitator may optionally select specific attendees or all attendees and initiate a one-to-one or group IM chat session with the selected attendees to begin a chat. The group IM session chat is initiated from within the MISD without providing the meeting facilitator with anything other than the e-mail addresses or e-mail IDs of the attendees.