Patents by Inventor Bradford B. Lowell

Bradford B. Lowell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genipin derivatives and uses thereof
    Patent number: 8093288
    Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: January 10, 2012
    Assignees: Beth Israel Deaconess Medical Center, Trustees of Boston University
    Inventors: Chen-Yu Zhang, Bradford B. Lowell, John A Porco, Jr., Ruichao Shen, Cheng T. Lin, Stefan Krauss
  • NOVEL GPR101 TRANSGENIC MICE AND METHODS OF USE THEREOF
    Publication number: 20110173706
    Abstract: The invention provides transgenic animals comprising a disruption in the endogenous GPR101 gene and methods of producing such transgenic animals. The invention further provides methods of identifying compounds that modulate GPR101 receptor proteins.
    Type: Application
    Filed: November 16, 2010
    Publication date: July 14, 2011
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Bradford B. Lowell, Harveen Dhillon
  • Genipin Derivatives and Uses Thereof
    Publication number: 20100168160
    Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
    Type: Application
    Filed: November 19, 2009
    Publication date: July 1, 2010
    Applicant: Beth Israel Deaconess Medical Center , Inc. And Trustees of Boston University
    Inventors: Chen-Yu Zhang, Bradford B. Lowell, John A. Porco, JR., Ruichao Shen, Cheng T. Lin, Stefan Krauss
  • Genipin derivatives and uses thereof
    Patent number: 7649014
    Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: January 19, 2010
    Assignees: Beth Israel Deaconess Medical Center, Inc., Trustees of Boston University
    Inventors: Chen-Yu Zhang, Bradford B. Lowell, John A Porco, Jr., Ruichao Shen, Cheng T. Lin, Stefan Krauss
  • Transgenic UCP2 knockout mouse and use thereof
    Patent number: 6365796
    Abstract: The present invention provides a transgenic non-human mammal which lacks a functional UCP2 gene. The UCP-2 deficient transgenic knockout mammal described herein provides a source of cells and animals useful to practice methods for the identification and/or evaluation of agents for their ability to affect signaling in cells, such as pancreatic &bgr;-cells, in which ATP serves a regulatory function. Further aspect of the invention provide a method for the identification of agents (e.g., therapeutic agents) which inhibit UCP2 activity; a method for the identification of agents which mimic UCP2 activity and a method of treating diseases or conditions associated with UCP2 function (e.g., negative regulation or uncoupling activity).
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: April 2, 2002
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Bradford B. Lowell, Chen-Yu Zhang, Catherine B. Chan, Michael B. Wheeler
  • Transgenic animals deficient in endogenous .beta..sub.3 -adrenergic receptor and uses thereof
    Patent number: 5789654
    Abstract: Disclosed a transgenic non-human mammal whose germ cells and somatic cells contain a knockout mutation in DNA encoding .beta..sub.3 -adrenergic receptor polypeptide.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: August 4, 1998
    Assignees: Beth Israel Hospital Association, Centre National de la Recherche Scientifique
    Inventors: Bradford B. Lowell, A. Donny Strosberg