Patents by Inventor Bradford C. Berk

Bradford C. Berk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting angiogenesis using inhibitors of G-protein-coupled receptor kinase interacting protein-1 (GIT1)
    Patent number: 9670259
    Abstract: The present invention is directed to methods and compositions comprising G-protein-coupled receptor kinase interacting protein-1 (GIT1) inhibitors that are suitable for inhibiting angiogenesis in a subject and treating related conditions.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 6, 2017
    Assignee: University of Rochester
    Inventors: Bradford C. Berk, Jinjiang Pang, Syamantak Majumder
  • MODULATION OF ANGIOGENESIS AND RELATED CONDITIONS USING INHIBITORS OF G-PROTEIN-COUPLED RECEPTOR KINASE INTERACTING PROTEIN-1 (GIT1)
    Publication number: 20160024163
    Abstract: The present invention is directed to methods and compositions comprising G-protein-coupled receptor kinase interacting protein-1 (GIT1) inhibitors that are suitable for inhibiting angiogenesis in a subject and treating related conditions.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Bradford C. BERK, Jinjiang PANG, Syamantak MAJUMDER
  • Thioredoxin interacting protein (TXNIP) as regulator of vascular function
    Patent number: 8999944
    Abstract: The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF-ASK1-JNK-p38 pathways.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: April 7, 2015
    Assignee: University of Rochester
    Inventor: Bradford C. Berk
  • Thioredoxin Interacting Protein (TXNIP) As Regulator Of Vascular Function
    Publication number: 20110097317
    Abstract: The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF- ASK1-JNK-p38 pathways.
    Type: Application
    Filed: January 20, 2006
    Publication date: April 28, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Bradford C. Berk