Abstract: The subject matter disclosed herein relates to methods of treating viral hemorrhagic fever in a subject in need thereof by administering a pharmaceutically acceptable dose of etoricoxib. In some embodiments, the etoricoxib is administered in combination with other suitable pharmaceutical compositions.

Abstract: The present disclosure relates to a method of treating symptoms of fever, pain, and inflammation in patients infected with a Viral Hemorrhagic Fever, the method comprising administering a COX-2 selective Non-Steroidal Anti-Inflammatory Drug (NSAID) at a sufficient dose to reduce both the symptoms and viral level of the infection, and matching the dose of a COX-2 selective NSAID to the time course of the Viral Hemorrhagic Fever to provide maximum anti-pyretic effect during the febrile phase of the infection and retain a lower maintenance dose during the remainder of the infection.

Abstract: Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, diet supplements) comprising deuterated caffeine. The provided compositions may be useful for treating and/or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder.

Abstract: The subject matter disclosed herein relates to rofecoxib, also known as TRM-201 or RXB-201, its method of manufacture, and use. In certain aspects, the highly pure or substantially pure rofecoxib as provided herein has a favorable purity profile and is the active ingredient in a pharmaceutical composition that is administered to treat or prevent a number of conditions, including pain associated with a condition caused by a bleeding disorder.

Abstract: Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, diet supplements) comprising deuterated caffeine. The provided compositions may be useful for treating and/or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder.

Abstract: An ingestible product is configured to be swallowed by a patient and includes: a drug portion that requires a Risk Evaluation and Mitigation Strategy (REMS) plan; and a wireless sensor portion configured to transmit sensor data concerning the drug portion to a remote device.