Patents by Inventor Bradford H. Hirth

Bradford H. Hirth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS
    Publication number: 20210171507
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose:N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: July 23, 2020
    Publication date: June 10, 2021
    Inventors: Bradford H. HIRTH, Craig SIEGEL
  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS
    Publication number: 20190322649
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: November 21, 2018
    Publication date: October 24, 2019
    Inventors: Bradford H. HIRTH, Craig Siegel
  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS
    Publication number: 20170334888
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: December 30, 2016
    Publication date: November 23, 2017
    Inventors: Bradford H. Hirth, Craig Siegel
  • Modulators of TNF-? signaling
    Patent number: 9579325
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: February 28, 2017
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Frederic Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Synthesis of UDP-glucose: -acylsphingosine glucosyl transferase inhibitors
    Patent number: 9546161
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: January 17, 2017
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS
    Publication number: 20150148534
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: June 26, 2014
    Publication date: May 28, 2015
    Inventors: Bradford H. Hirth, Craig Siegel
  • Modulators Of TNF-Alpha Signaling
    Publication number: 20150126512
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Application
    Filed: November 25, 2014
    Publication date: May 7, 2015
    Applicant: GENZYME CORPORATION
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Frederic Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Modulators of TNF-? signaling
    Patent number: 8921547
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: December 30, 2014
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Frederic Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Synthesis of UDP-Glucose: -acylsphingosine glucosyl transferase inhibitors
    Patent number: 8779163
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: July 15, 2014
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • Modulators of TNF-Alpha Signaling
    Publication number: 20130310388
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 21, 2013
    Applicant: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, JR., Bradford H. Hirth, Fred Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Modulators of TNF-?signaling
    Patent number: 8518999
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: August 27, 2013
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Fred Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS
    Publication number: 20120296088
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: March 14, 2012
    Publication date: November 22, 2012
    Inventors: Bradford H. Hirth, Craig Siegel
  • Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors
    Patent number: 8138353
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: March 20, 2012
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS
    Publication number: 20110003987
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Inventors: Bradford H. Hirth, Craig Siegel
  • Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors
    Patent number: 7763738
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: July 27, 2010
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • Tetrahydroisoquinoline derivatives for treating protein trafficking diseases
    Patent number: 7541466
    Abstract: Tetrahydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: June 2, 2009
    Assignee: Genzyme Corporation
    Inventors: Marko J. Pregel, Bradford H. Hirth, John L. Kane, Jr., Shuang Qiao, Jill Gregory, Lisa Cuff
  • Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors
    Patent number: 7265228
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: September 4, 2007
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Patent number: 7041831
    Abstract: Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound represented by Structural Formula (II):
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: May 9, 2006
    Assignee: Genzyme Corporation
    Inventor: Bradford H. Hirth
  • Modulators of TNF-? signaling
    Patent number: 7034031
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: April 25, 2006
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Fred Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Modulators of TNF-? signaling
    Patent number: 6969728
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: November 29, 2005
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Fred Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann