Patents by Inventor Bradford Hirth

Bradford Hirth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroisoquinoline derivatives for treating protein trafficking diseases
    Publication number: 20050176761
    Abstract: Tetrhydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.
    Type: Application
    Filed: December 7, 2004
    Publication date: August 11, 2005
    Applicant: Genzyme Corporation
    Inventors: Marko Pregel, Bradford Hirth, John Kane, Shuang Qiao, Jill Gregory, Lisa Cuff
  • Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20050075381
    Abstract: Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound represented by Structural Formula (II):
    Type: Application
    Filed: November 23, 2004
    Publication date: April 7, 2005
    Inventor: Bradford Hirth
  • Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20050009872
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: August 12, 2004
    Publication date: January 13, 2005
    Applicant: Genzyme Corporation
    Inventors: Bradford Hirth, Craig Siegel