Patents by Inventor Bradford James Duft

Bradford James Duft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHANNEL MODULATORS
    Publication number: 20230174980
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Application
    Filed: July 29, 2022
    Publication date: June 8, 2023
    Inventors: Colin Richard GREEN, Yeri KIM, Anthony PHILLIPS, Bradford James DUFT
  • COMPOSITIONS AND METHODS FOR RESCUING RETINAL AND CHOROIDAL STRUCTURE AND FUNCTION
    Publication number: 20220401408
    Abstract: The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, to rescue or restore retinal function, to rescue or restore retinal structure, and/or to rescue or restore choroidal structure and/or function in chronic retinal and other disorders.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 22, 2022
    Inventors: Colin Richard GREEN, Nasir Mat NOR, Monica Liliana Acosta ETCHEBARNE, Bradford James DUFT
  • CYTOKINE MODULATION
    Publication number: 20220288163
    Abstract: The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Inventors: Colin Richard GREEN, Odunayo Omolola Boluwarin MUGISHO, Bradford James DUFT
  • Channel modulators
    Patent number: 11401516
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: August 2, 2022
    Assignees: AUCKLAND UNISERVICES LIMITED, OCUNEXUS THERAPEUTICS, INC.
    Inventors: Colin Richard Green, Yeri Kim, Anthony Phillips, Bradford James Duft
  • Cytokine modulation
    Patent number: 11344603
    Abstract: The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: May 31, 2022
    Assignees: AUCKLAND UNISERVICES LIMITED, OCUNEXUS THERAPEUTICS, INC.
    Inventors: Colin Richard Green, Odunayo Omolola Boluwarin Mugisho, Bradford James Duft
  • CHANNEL MODULATORS
    Publication number: 20210115445
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Application
    Filed: December 11, 2020
    Publication date: April 22, 2021
    Inventors: Colin Richard GREEN, Yeri KIM, Anthony PHILLIPS, Bradford James DUFT
  • COMPOSITIONS AND METHODS FOR PROTECTING EPITHELIAL AND BARRIER INTEGRITY
    Publication number: 20210000911
    Abstract: The inventions relate to the use of hemichannel blockers to modulate BRB integrity and function, RPE integrity and function, tight junction integrity and function, ZO-1 internalization, gap junction internalization, and/or type IV collagen levels in a subject.
    Type: Application
    Filed: April 23, 2020
    Publication date: January 7, 2021
    Inventors: Odunayo Omolola Boluwarin MUGISHO, Colin Richard GREEN, Bradford James DUFT
  • CHANNEL MODULATORS
    Publication number: 20200263175
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Application
    Filed: November 4, 2019
    Publication date: August 20, 2020
    Inventors: Colin Richard GREEN, Yeri KIM, Anthony PHILLIPS, Bradford James DUFT
  • CHANNEL MODULATORS
    Publication number: 20200239889
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Application
    Filed: November 4, 2019
    Publication date: July 30, 2020
    Inventors: Colin Richard GREEN, Yeri KIM, Anthony PHILLIPS, Bradford James DUFT
  • NOVEL PEPTIDES AND PEPTIDOMIMETICS
    Publication number: 20200129582
    Abstract: Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions
    Type: Application
    Filed: October 30, 2019
    Publication date: April 30, 2020
    Inventors: Colin Richard GREEN, Yeri KIM, Bradford James DUFT
  • Channel modulators
    Patent number: 10465188
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: November 5, 2019
    Assignees: AUCKLAND UNISERVICES LIMITED, OCUNEXUS THERAPEUTICS, INC
    Inventors: Colin Richard Green, Yeri Kim, Anthony Phillips, Bradford James Duft
  • CYTOKINE MODULATION
    Publication number: 20190030122
    Abstract: The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 31, 2019
    Inventors: Colin Richard GREEN, Odunayo Omolola Boluwarin MUGISHO, Bradford James DUFT
  • NOVEL PEPTIDES AND PEPTIDOMIMETICS
    Publication number: 20180008664
    Abstract: Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions.
    Type: Application
    Filed: May 2, 2017
    Publication date: January 11, 2018
    Inventors: Colin Richard GREEN, Yeri KIM, Bradford James DUFT
  • Treatment of fibrotic conditions
    Patent number: 9738892
    Abstract: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: August 22, 2017
    Assignee: CODA THERAPEUTICS, INC.
    Inventors: David Lawrence Becker, Colin Richard Green, Bradford James Duft
  • Impaired wound healing compositions and treatments
    Patent number: 9637745
    Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: May 2, 2017
    Assignee: CoDa Therapeutics, Inc.
    Inventors: David Lawrence Becker, Colin Richard Green, Bradford James Duft
  • Medical devices
    Patent number: 9561311
    Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: February 7, 2017
    Assignee: CoDA Therapeutics, Inc.
    Inventors: David Lawrence Becker, Colin Richard Green, Bradford James Duft
  • IMPROVED WOUND HEALING COMPOSITIONS AND TREATMENTS
    Publication number: 20160264977
    Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
    Type: Application
    Filed: March 15, 2014
    Publication date: September 15, 2016
    Applicant: CoDa Therapeutics, Inc.
    Inventors: Anthony PHILLIPS, David EISENBUD, Scott BANNAN, David POOL, Grove MATSUOKA, Tracey SUNDERLAND, Bradford James DUFT
  • CHANNEL MODULATORS
    Publication number: 20160177298
    Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
    Type: Application
    Filed: August 21, 2015
    Publication date: June 23, 2016
    Inventors: Colin Richard GREEN, Yeri KIM, Anthony PHILLIPS, Bradford James DUFT
  • IMPAIRED WOUND HEALING COMPOSITIONS AND TREATMENTS
    Publication number: 20150315598
    Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 5, 2015
    Inventors: David Lawrence BECKER, Colin Richard GREEN, Bradford James DUFT
  • MEDICAL DEVICES
    Publication number: 20150297804
    Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.
    Type: Application
    Filed: May 18, 2015
    Publication date: October 22, 2015
    Inventors: David Lawrence BECKER, Colin Richard GREEN, Bradford James DUFT