Patents by Inventor Bradford L. McRae

Bradford L. McRae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD40 ANTIBODIES AND USES THEREOF
    Publication number: 20220289858
    Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.
    Type: Application
    Filed: October 7, 2021
    Publication date: September 15, 2022
    Inventors: Lorenzo Benatuil, Maria A. Argiriadi, Bradford L. Mcrae, Chung-Ming Hsieh, David A. Egan, John E. Harlan, Russell A. Judge, Rui Wang, Gillian A. Kingsbury
  • ANTI-CD40 ANTIBODIES AND USES THEREOF
    Publication number: 20190359725
    Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.
    Type: Application
    Filed: December 21, 2018
    Publication date: November 28, 2019
    Inventors: Lorenzo Benatuil, Maria A. Argiriadi, Bradford L. McRae, Chung-Ming Hsieh, David A. Egan, John E. Harlan, Russell A. Judge, Rui Wang, Gillian A. Kingsbury
  • Anti-CD40 antibodies
    Patent number: 10174121
    Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: January 8, 2019
    Assignee: ABBVIE, INC.
    Inventors: Lorenzo Benatuil, Bradford L. McRae, Chung-Ming Hsieh, Rui Wang
  • IL-17 binding proteins
    Patent number: 9663587
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 30, 2017
    Assignee: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • ANTI-CD40 ANTIBODIES AND USES THEREOF
    Publication number: 20160347850
    Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Inventors: Lorenzo Benatuil, Bradford L. McRae, Maria A. Argiriadi, Chung-Ming Hsieh
  • IL-17 binding proteins
    Patent number: 9481736
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: November 1, 2016
    Assignee: AbbVie, Inc.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 binding proteins
    Patent number: 9481735
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: November 1, 2016
    Assignee: AbbVie Inc.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140356909
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 28, 2014
    Publication date: December 4, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140348856
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 25, 2014
    Publication date: November 27, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140348834
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 23, 2014
    Publication date: November 27, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140343267
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 24, 2014
    Publication date: November 20, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140335564
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 22, 2014
    Publication date: November 13, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 binding proteins
    Patent number: 8779101
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: July 15, 2014
    Assignee: AbbVie, Inc.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • IL-17 BINDING PROTEINS
    Publication number: 20140017246
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: August 5, 2013
    Publication date: January 16, 2014
    Applicant: ABBVIE INC.
    Inventors: Chung-Ming Hsieh, Margaret Hugunin, Anwar Murtaza, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Jennifer M. Perez, Suju Zhong, Edit Tarcsa, Anca Clabbers, Craig Wallace, Shaughn H. Bryant, Mary R. Leddy
  • DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES
    Publication number: 20130171146
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: August 21, 2012
    Publication date: July 4, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • Dual-specific IL-1?/IL-1? antibodies
    Patent number: 8324350
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: December 4, 2012
    Assignee: Abbott Laboratories
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • IL-17 BINDING PROTEINS
    Publication number: 20100266531
    Abstract: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
    Type: Application
    Filed: March 5, 2010
    Publication date: October 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: CHUNG-MING HSIEH, MARGARET HUGUNIN, ANWAR MURTAZA, BRADFORD L. MCRAE, YULIYA KUTSKOVA, JOHN E. MEMMOTT, JENNIFER M. PEREZ, SUJU ZHONG, EDIT TARCSA, ANCA CLABBERS, CRAIG WALLACE, SHAUGHN H. BRYANT, MARY R. LEDDY
  • Dual-specific IL-1A/IL-1b antibodies
    Publication number: 20090291081
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: December 28, 2007
    Publication date: November 26, 2009
    Inventors: Chung-Ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna