Patents by Inventor Bradford McGwire

Bradford McGwire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live attenuated parasitic vaccine
    Patent number: 11110132
    Abstract: Disclosed herein is an avirulent live vaccine that involves a recombinant protozoan from the order Trypanosomatida having a knocked out or silenced cyclophilin gene, wherein the cyclophilin gene comprises T. cruzi cyclophilin 19 (TcCyp19) gene, or an orthologue thereof. Also disclosed is a method or inducing a protective immune response in a subject that involves administering to the subject a vaccine disclosed herein. Also disclosed is a method of treating or preventing Chagas disease, African trypanosomiasis, and/or leishmaniasis in a subject that involves administering to the subject a vaccine disclosed herein.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: September 7, 2021
    Assignee: Ohio State Innovation Foundation
    Inventor: Bradford McGwire
  • LIVE ATTENUATED PARASITIC VACCINE
    Publication number: 20200147148
    Abstract: Disclosed herein is an avirulent live vaccine that involves a recombinant protozoan from the order Trypanosomatida having a knocked out or silenced cyclophilin gene, wherein the cyclophilin gene comprises T. cruzi cyclophilin 19 (TcCyp19) gene, or an orthologue thereof. Also disclosed is a method or inducing a protective immune response in a subject that involves administering to the subject a vaccine disclosed herein. Also disclosed is a method of treating or preventing Chagas disease, African trypanosomiasis, and/or leishmaniasis in a subject that involves administering to the subject a vaccine disclosed herein.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 14, 2020
    Inventor: Bradford McGwire