Patents by Inventor Bradford Michael Stadler

Bradford Michael Stadler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chelated nanoceria for the treatment of oxidative stress
    Patent number: 10751366
    Abstract: A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: August 25, 2020
    Assignee: Cerion LLC
    Inventors: Bradford Michael Stadler, David Wallace Sandford
  • CHELATED NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS
    Publication number: 20170128488
    Abstract: A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Applicant: CERION, LLC
    Inventors: BRADFORD MICHAEL STADLER, DAVID WALLACE SANDFORD
  • Chelated nanoceria for the treatment of oxidative stress
    Patent number: 9549950
    Abstract: A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: January 24, 2017
    Assignee: CERION, LLC
    Inventors: Bradford Michael Stadler, David Wallace Sandford
  • Nanoparticles of cerium and amino acids
    Patent number: 9308265
    Abstract: A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an ?-amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: April 12, 2016
    Assignee: CERION LLC
    Inventors: Wendi Ann Costanzo, Kenneth Joseph Reed, Bradford Michael Stadler
  • CHELATED NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS
    Publication number: 20140322333
    Abstract: A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.
    Type: Application
    Filed: April 25, 2014
    Publication date: October 30, 2014
    Applicant: CERION ENTERPRISES, LLC
    Inventors: Bradford Michael Stadler, David Wallace Sandford
  • NANOPARTICLES OF CERIUM AND AMINO ACIDS
    Publication number: 20130273659
    Abstract: A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an ?-amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 17, 2013
    Applicant: Cerion Enterprises, LLC
    Inventors: Wendi Ann Costanzo, Kenneth Joseph Reed, Bradford Michael Stadler