Patents by Inventor Bradlee L. Heckmann

Bradlee L. Heckmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATION OF LC3-ASSOCIATED ENDOCYTOSIS PATHWAY AND GENETICALLY MODIFIED NON-HUMAN ANIMALS AS A MODEL OF NEUROINFLAMMATION AND NEURODEGENERATION
    Publication number: 20220104468
    Abstract: Compositions and methods are provided for modifying and treating neuroinflammatory and neurodegenerative diseases. The methods and compositions can be used to ameliorate the effects of a deficiency in the LC3-associated endocytosis (LANDO) pathway for clearing ?-amyloid. Thus, methods are further provided for modulating ?-amyloid clearance using an effective amount of a pharmaceutical composition that targets the LANDO pathway. Accordingly, pharmaceutical compositions that target the LANDO pathway are provided herein. The methods and compositions described herein can be used to treat neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease.
    Type: Application
    Filed: January 22, 2020
    Publication date: April 7, 2022
    Applicant: St. Jude Children's Research Hospital
    Inventors: Bradlee L. Heckmann, Douglas R. Green