Abstract: A method for downhole cutting structure design. The method comprises executing a first computer-simulated drilling by at least one downhole cutting structure of a wellbore into a subsurface formation based on an original data set that includes at least one drilling parameter and at least one downhole cutting structure attribute associated with an actual drilling of the wellbore using the at least one downhole cutting structure into the subsurface formation. The method comprises recursively performing the following operations until a drilling performance threshold is satisfied, changing at least one of the at least one drilling parameter and the at least one downhole cutting structure attribute in the original data set to create a modified data set and executing a second computer-simulated drilling by the at least one downhole cutting structure of the wellbore into the subsurface formation based and the modified data set.

Abstract: Disclosed are methods of synthesizing poly(ester urea)s.

Abstract: Disclosed in some examples are methods, systems, devices, and machine-readable mediums which monitor for file system element transfers to and from both the endpoint and authorized accounts on network-based service providers (e.g., cloud-based storage). The system uses the capabilities of monitoring both the network-based service and the client computing device to filter out legitimate uploads to authorized network-based services and legitimate downloads to authorized computing devices. By matching events, it filters out events that are likely legitimate, the system may provide more accurate information, notifications, awareness, and unmatched event indications.

Abstract: Multiple subterranean probes at an area of land detect soil conditions and wirelessly transmit soil condition information to a service provider's backend server or to a technician's hand-held wireless device. The server provides multiple user interface screens of a customer application that display soil condition information and irrigation system status. Local micro weather stations may determine and wirelessly transmit weather condition information to the server. An energy emission detecting appliance may be used to acquire information usable to determine fluorescence of grass. The determined fluorescence may be used to train a learning model. The learning trained model may use historical soil condition and fluorescence information to determine a stress level corresponding to the grass. The stress level may be used to modify an irrigation or fertilization schedule.

Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.

Abstract: A golf club head having a flexible channel to improve the performance of the club head, and a channel tuning system to reduce undesirable club head characteristics introduced, or heightened, via the flexible channel. The channel tuning system includes a sole engaging channel tuning element in contact with the sole and the channel. The club head may include an aerodynamic configuration, as well as a body tuning system.

Abstract: A fluid pump includes a pump element where rotation of the pump element generates suction at the inlet and pressure at the outlet to move fluid through a fluid path. An inlet orifice directs a portion of the fluid through the accessory fluid path that includes a low-restriction return path providing a continuous flow of the fluid through the accessory fluid path and to an outlet orifice. A circuit board housing includes a contoured portion and a PCB with a thermistor in communication with contoured portion. The continuous flow is directed between the contoured portion and the outlet orifice between a rotor and the outer wall. The low-restriction return path maintains a temperature of the continuous flow of the fluid within the contoured portion of the accessory fluid path to be similar to a temperature of the fluid in the fluid path.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize, index, search, and present time series data based on searches. Time series data are sequences of time stamped records occurring in one or more usually continuous streams, representing some type of activity. In one embodiment, time series data is stored as discrete events time stamps. A search is received and relevant event information is retrieved based in whole or in part on the time stamp, a keyword indexing mechanism, or statistical indices calculated at the time of the search.

Abstract: Hydrofoil fishing lure apparatus for use with trolling techniques behind a boat. In one embodiment, the hydrofoil fishing lure apparatus includes an artificial lure having a body. A hydrofoil that includes a strut and a lifting surface, with the strut for the hydrofoil being attached to the body of the artificial lure is also included. In some variants, the artificial lure may be modeled after flying fish species. Wing retraction elements may be utilized on the hydrofoil to retract or expand the wings of the flying fish to provide for a more natural presentation. Other variants described herein include fishing lure platforms that include a hydrofoil that allow for the mounting of frozen, live, or other types of artificial baits on the hydrofoil itself.

Abstract: Skin hydration is necessary to maintain the epidermal barrier, minimize adverse environmental influences, and reduce cell stress. Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically and cosmetically acceptable salts thereof, and compositions, methods, and uses that may be used for skin hydration. Also reported herein is a scalable method for synthesizing compounds of Formula (I). The compounds provided herein are responsible for improved skin penetration and/or retention and are therefore useful for the treatment and/or prevention of various diseases, disorders, or conditions to protect human skin.

Abstract: Transmitting and receiving mud pulse pressure waves at a downhole device. The mud pulse pressure waves may be transmitted from a surface mud pulser and/or by a downhole mud pulser to a downhole device. The mud pulse pressure waves may be detected directly by a transducer or indirectly by detecting physical changes induced in the downhole tool by the pressure waves of the mud pulse. The detected physical changes can be converted to a digital signal for use by the downhole tool. The mud pulse pressure waves may encode information including data, or instructions to the downhole devices.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Thermal control system for aircraft main landing gear wheel wells and related methods are disclosed. An example thermal control system includes a conduit defining a fluid passageway between an inlet and an outlet. The inlet of the conduit positioned in fluid communication with a landing gear wheel well and the outlet of the conduit positioned in fluid communication with the atmosphere. The conduit generates a pressure differential through the fluid passageway between the inlet and the outlet to exhaust heat from the landing gear wheel well to the atmosphere.

Abstract: A fenestration hinge assembly includes a first leaf rotatably coupled with a second leaf. The first and second leaves each include one or more leaf knuckles. The first and second leaf knuckles are at least partially received within a hinge cavity of a recessed escutcheon, the recessed escutcheon configured for recessed installation within a panel or frame of a fenestration assembly. The fenestration hinge assembly includes a lateral adjustment plate movably coupled with a remainder of the second leaf. The lateral adjustment plate is configured to position at least a portion of the second leaf laterally relative to one of the frame or the panel. The fenestration hinge assembly includes an adjustable hinge configured for elevation adjustment. The adjustable hinge includes an elevation adjustment pin interconnecting the first and second leaf knuckles. The elevation adjustment pin is configured to position the second leaf vertically relative to the first leaf.

Abstract: A congested network link is identified. Applications that are contributing to the congestion are also identified. The contribution of each of the identified applications to the congestion is then determined in order to determine whether the application's usage of the network should be throttled. A control signal is generated in order to indicate to the application that it is to perform an application-specific throttling operation to reduce the network bandwidth consumed by the application. If the application-specific throttling does not sufficiently reduce network congestion, a more aggressive throttling operation is performed.

Abstract: An autonomous vehicle receives geographic location data defined via a mobile computing device operated by a user. The geographic location data is indicative of a device position of the mobile computing device. The autonomous vehicle also receives image data generated by the mobile computing device. The image data is indicative of a surrounding position nearby the device position. The surrounding position is selected from an image captured by a camera of the mobile computing device. A requested vehicle position (e.g., a pick-up or drop-off location) is set for a trip of the user in the autonomous vehicle based on the geographic location data and the image data. A route from a current vehicle position of the autonomous vehicle to the requested vehicle position for the trip of the user in the autonomous vehicle is generated. Moreover, the autonomous vehicle can follow the route to the requested vehicle position.

Abstract: A system and method is disclosed for automated cross-node communication in a distributed directed acyclic graph. The method can include identifying a directed acyclic graph (“DAG”) overlaying a plurality of nodes and identifying the nodes underlying the DAG. A subordinate DAG can be generated in an entry vertex of the DAG. The subordinate DAG can include a vertex for each of the nodes underlying the DAG. Data and metadata can be received at the entry vertex. The data can be delivered to a next vertex in the DAG, and the metadata can be communicated to nodes underlying the DAG via the subordinate DAG.

Abstract: A congested network link is identified. Applications that are contributing to the congestion are also identified. The contribution of each of the identified applications to the congestion is then determined in order to determine whether the application's usage of the network should be throttled. A control signal is generated in order to indicate to the application that it is to perform an application-specific throttling operation to reduce the network bandwidth consumed by the application. If the application-specific throttling does not sufficiently reduce network congestion, a more aggressive throttling operation is performed.

Abstract: Multiple subterranean probes at an area of land detect soil conditions and wirelessly transmit soil condition information to a service provider's backend server or to a technician's hand-held wireless device. The server provides multiple user interface screens of a customer application that display soil condition information and irrigation's system status. Local micro weather stations may determine and wirelessly transmit weather condition information to the server. An installer may use the customer application to determine that received signal strength at a given probe is weak and should thus be relocated, or to determine refined location information corresponding to the probe. Historical soil condition information and artificial intelligence may predict soil conditions where a previously installed probe has been moved or quit working. Probes' housings seal internal electronics, including soil condition sensors, wireless communication modules, processors, and memory.

Abstract: A device for hailing a vehicle includes a location sensor outputting location information indicative of a location of the device. The device further includes a device interface configured to receive an input from a user of the device. Responsive to the input, a transmitter of the device transmits the location information, input information, and identification information for the device to a dispatch server system. The transmitter is further configured to route the location information, the input information, and the identification information for the device to only the dispatch server system. The identification information is used by the dispatch server system to set a predefined location associated with the identification information as a destination for a trip for the user in the vehicle. The predefined location is defined in an account corresponding to the identification information of the device maintained by the dispatch server system prior to receipt of the input.