Patents by Inventor Bradley A. Haltli

Bradley A. Haltli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-ACYL-TYROSINE DERIVATIVES AND USES THEREOF
    Publication number: 20220371989
    Abstract: Provided herein are compounds of Formula A, methods for the preparation thereof, and uses thereof for treating or preventing bacterial infections.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 24, 2022
    Applicant: Sederma
    Inventors: Logan William MacIntyre, Russell Greig Kerr, Bradley Haltli
  • Elaiophylin biosynthetic gene cluster
    Patent number: 7595187
    Abstract: The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that contains at least one gene or a part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of elaiophylin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 29, 2009
    Assignee: Wyeth
    Inventor: Bradley A. Haltli
  • Actinomadura Chromoprotein, Apoprotein and Gene Cluster
    Publication number: 20080274959
    Abstract: The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.
    Type: Application
    Filed: December 16, 2005
    Publication date: November 6, 2008
    Applicant: Wyeth
    Inventors: Bradley A. Haltli, Haiyin He, Ying Huang, Sridhar Krishna Rabindran, Jiang Wu, Min He
  • Elaiophylin biosynthetic gene cluster
    Publication number: 20060141583
    Abstract: The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that contains at least one gene or a part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of elaiophylin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.
    Type: Application
    Filed: November 14, 2005
    Publication date: June 29, 2006
    Inventor: Bradley Haltli
  • Biosynthetic gene cluster for the production of a complex polyketide
    Publication number: 20050272133
    Abstract: A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Min He, John Hucul, Bradley Haltli, Melissa Wagenaar, Edmund Graziani, Mia Summers, Kerry Kulowski, Kevin Pong