Patents by Inventor Bradley A. Ozenberger
Bradley A. Ozenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7745164Abstract: The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e.g., mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.Type: GrantFiled: December 26, 2006Date of Patent: June 29, 2010Assignee: Wyeth LLCInventors: Wei Liu, Bradley A. Ozenberger, Leeying Wu, Ching-Hsiung Frederick Lo, Steven A. Haney, Hemchand Sookdeo, Jee Hyung Lee
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Publication number: 20070113296Abstract: The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.Type: ApplicationFiled: December 26, 2006Publication date: May 17, 2007Inventors: Wei Liu, Bradley Ozenberger, Leeying Wu, Ching-Hsiung Lo, Steven Haney, Hemchand Sookdeo, Jee Hyung Lee
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Publication number: 20060248605Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: ApplicationFiled: July 12, 2006Publication date: November 2, 2006Applicant: WyethInventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
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Patent number: 7101973Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: GrantFiled: July 16, 2004Date of Patent: September 5, 2006Assignee: WyethInventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia, David Howland
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Patent number: 7005295Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.Type: GrantFiled: January 31, 2001Date of Patent: February 28, 2006Assignee: WyethInventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia
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Publication number: 20050282999Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: ApplicationFiled: July 16, 2004Publication date: December 22, 2005Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
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Publication number: 20050214830Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.Type: ApplicationFiled: February 7, 2005Publication date: September 29, 2005Applicant: WyethInventors: Bradley Ozenberger, Eileen Kajkowski, Ching-Hsiung Frederick Lo, Heidi Sofia
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Publication number: 20050170408Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.Type: ApplicationFiled: February 7, 2005Publication date: August 4, 2005Applicant: WyethInventors: Bradley Ozenberger, Eileen Kajkowski, Ching-Hsiung Lo, Heidi Sofia
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Publication number: 20050096460Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: ApplicationFiled: July 16, 2004Publication date: May 5, 2005Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
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Publication number: 20040248168Abstract: The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.Type: ApplicationFiled: March 25, 2004Publication date: December 9, 2004Inventors: Wei Liu, Bradley A. Ozenberger, Leeying Wu, Ching-Hsiung Frederick Lo, Steven A. Haney, Hemchand Sookdeo, Jee Hyung Lee
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Patent number: 6787319Abstract: Novel proteins which bind human &bgr;-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: GrantFiled: May 9, 2001Date of Patent: September 7, 2004Assignee: American Home Products Corp.Inventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia, David Howland
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Patent number: 6673540Abstract: This invention relates to modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; the fusion protein comprising a first peptide of a peptide binding pair, or segment of the first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, the fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriptional aType: GrantFiled: November 17, 2000Date of Patent: January 6, 2004Assignee: American Cyanamid CompanyInventors: Kathleen H. Young, Bradley A. Ozenberger
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Publication number: 20030096356Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.Type: ApplicationFiled: July 18, 2002Publication date: May 22, 2003Applicant: WyethInventors: Bradley A. Ozenberger, Eileen M. Kajkowski, Ching-Hsiung Frederick Lo, Heidi Sofia
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Publication number: 20020146760Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.Type: ApplicationFiled: April 12, 2001Publication date: October 10, 2002Applicant: American Home Products CorporationInventors: Bradley A. Ozenberger, Eileen M. Kajkowski, Ching-Hsiung Frederick Lo, Stephen G. Walker, Heidi Sofia
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Publication number: 20020058267Abstract: Novel proteins which bind human &bgr;-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.Type: ApplicationFiled: May 9, 2001Publication date: May 16, 2002Applicant: American Home Products CorporationInventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia, David Howland
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Patent number: 6284519Abstract: This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriType: GrantFiled: May 6, 1999Date of Patent: September 4, 2001Assignee: American Cyanamid CompanyInventors: Kathleen H. Young, Bradley A. Ozenberger
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Patent number: 6251602Abstract: This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriType: GrantFiled: March 8, 1999Date of Patent: June 26, 2001Assignee: American Cyanamid CompanyInventors: Kathleen H. Young, Bradley A. Ozenberger
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Patent number: 6046026Abstract: Disclosed are novel DNAs encoding polypeptides related to opioid receptors, methods for expressing and isolating such polypeptides, and methods of use thereof. Also disclosed are vectors for expressing the novel DNAs of the invention.Type: GrantFiled: September 12, 1996Date of Patent: April 4, 2000Assignee: American Cyanamid CompanyInventors: Cecil Mark Eppler, Bradley A. Ozenberger, Jeffrey D. Hulmes
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Patent number: 6005072Abstract: Isolated DNAs encoding opiorph receptor polypeptides are provided. Recombinant cloning vectors which include these DNA sequences and cells which include these vectors are also provided. Methods for detecting the expression, in a tissue, of mRNA encoding a polypeptide encoded by this DNA are encompassed as well as methods for producing these polypeptides. These isolated polypeptides and antibodies to these polypeptides are also contemplated.Type: GrantFiled: May 30, 1995Date of Patent: December 21, 1999Assignee: American Cyanamid CompanyInventors: Cecil Mark Eppler, Bradley A. Ozenberger, Jeffrey D. Hulmes
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Patent number: 5989808Abstract: This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriType: GrantFiled: June 14, 1994Date of Patent: November 23, 1999Assignee: American Cyanamid CompanyInventors: Kathleen H. Young, Bradley A. Ozenberger