Abstract: Compositions and methods are described for the delivery of a fully human post-translationally modified therapeutic monoclonal antibody that binds to CGRP or CGRP receptor to a human subject for the treatment or prevention of migraines and cluster headaches. The antibodies may be delivered by gene therapy vectors, particularly rAAV vectors. Also provided are dual transgene constructs for the delivery of anti-CGRP and anti-CGRP receptor antibodies or antigen binding fragments thereof.

Abstract: A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel.

Abstract: A rotating separator including a filter element extending axially along a longitudinal axis and including a first endplate, a second endplate, and a separating element. The first endplate includes a center tube. The second endplate is coupled to the first endplate and includes a central aperture having a perimeter and receiving the center tube. The filter element also includes an axially extending slot and an axially extending protrusion positioned on one of the first endplate and the second endplate and configured to engage with each other. The first and second endplates form an interior cavity when coupled together. The rotating separator includes a filter structure positioned within the interior cavity.

Abstract: An apparatus comprises processing circuitry to implement an encrypted processing unit (EPU) client comprising a secure enclave, an encrypted processing unit (EPU) server comprising an encrypted processing unit (EPU) communicatively coupled to the secure enclave and at least one pseudo-clock generator, and a memory server communicatively coupled to the encrypted processing unit (EPU) client and to the encrypted processing unit (EPU) server, the memory server to manage a homomorphically encrypted memory.

Abstract: An improved AR/VR operation includes receiving, by a server computing device, encrypted AR/VR user data and cleartext metadata associated with the encrypted AR/VR user data from a client computing device; getting server data based at least in part on cleartext metadata; encoding the server data; performing an AR/VR process on the encrypted AR/VR user data and the encoded server data to generate encrypted AR/VR results; and sending the encrypted AR/VR results to the client computing device.

Abstract: A capacitive pressure transducer includes a shielded spacer positioned between the capacitor electrodes and driven with a separate voltage source.

Abstract: A compound helicopter includes a fuselage including a fuselage airframe, a translational thrust system coupled to the fuselage airframe and a pylon assembly subject to vibration. The pylon assembly includes a transmission and a rotor system having a main rotor assembly. The compound helicopter also includes a main rotor vibration isolation system including a plurality of augmented liquid inertia vibration eliminator units each having an isolation frequency and each coupled between the fuselage airframe and the pylon assembly to reduce transmission of the pylon assembly vibration to the fuselage airframe at the isolation frequency. Each augmented liquid inertia vibration eliminator unit includes at least one active tuning element movable to tune the isolation frequency thereof.

Abstract: An electronic aiming system includes an electro-mechanical reticle having a plurality of electrically powered holdover indicators disposed on a primary crosshair of the reticle, the holdover indicators configured to be individually selected and energized to a visible state, a rangefinder configured to generate range data, a computing device configured to generate ballistics data; and a processor configured to receive the range data and ballistics data, select, based at least in part on either or both of the range data and ballistics data, one or more of the holdover indicators, and energize the selected holdover indicator or indicators to the visible state

Abstract: Systems and methods for controlling a display system. The methods comprise: detecting an occurrence of an event; initiating a display session based on the event being of an event type to trigger a display session; and selecting media content (MC) for display by computing devices (ICDs) (wherein ICDs are located in areas or sections (SA/S) of a venue); selecting a first SA/S at which display of MC is to begin; identifying first CDs (FCDs) that are located in the first SA/S; causing FCDs to notify users that FCDs are to be moved into positions in which first pixel panels are visible by persons located outside of the first SA/S; and causing each FCD to display a respective pixel portion of a first electronic graphic (FEI) contained in MC, whereby an entirety of FEI is displayed collectively by FCDs.

Abstract: A device may receive, from a user device, a transaction request associated with a first entity and identify a distributed ledger associated with the first entity, the distributed ledger including a set of blocks recording work data associated with the first entity. The set of blocks may include: a first subset of blocks including data specifying work performed by the first entity, and a second subset of blocks including data verifying a portion of the work performed by the first entity and specified by the data included in the first subset of blocks. The device may determine that a transaction, associated with the transaction request, is associated with the first subset of blocks and the second subset of blocks. Based on predetermined instructions that correspond to the transaction and the distributed ledger, the device may perform the transaction.

Abstract: A muffler for use with an internal combustion engine is provided. The muffler includes a first tube configured to receive a first exhaust stream. The first tube includes a first inlet portion, a first outlet portion spaced apart from the first inlet portion, and a first intermediate portion extending between the first inlet portion and the first outlet portion. The muffler also includes a second tube configured to receive a second exhaust stream. The second tube includes a second inlet portion, a second outlet portion spaced apart from the second inlet portion, and a second intermediate portion extending between the second inlet portion and the second outlet portion. The first intermediate portion and the second intermediate portion cross each other, are at least partially stacked on each other, and are in fluid communication with each other.

Abstract: A spherical bearing includes an inner member that has an exterior surface extending a first width between axial ends thereof and having a first central plane located equidistant between the axial ends. The spherical bearing includes an outer member with a inner surface having a maximum inside diameter at an apex plane and extending a second width between opposing ends thereof and having second central plane located equidistant between the ends thereof. The inner member is disposed in an interior area of the outer member. The first central plane is coplanar with the apex plane and is axially offset from the second central plane. One of the opposing axial ends of the inner member is located entirely in the interior area and axially inward from ends of the outer member when the inner member is angularly misaligned relative to the outer member at non-zero angles up to 7 degrees.

Abstract: Systems include a plurality of sensors coupled to a person support apparatus, at least one moisture sensor configured to sense a moisture level between the person and the support surface, and at least one computing device coupled to the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor. The at least one computing device receives data from the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor, obtains data from an electronic medical record associated with the person supported by the person support apparatus, calculates a pressure injury score indicative of a likelihood that the person will develop a pressure injury based on the data from the plurality of sensors, the at least one moisture sensor, and the electronic medical record, and alters a treatment plan for the person based on the calculated pressure injury score.

Abstract: Referring to the figures generally, a rotating filter cartridge includes a first endcap, a second endcap, and a filter media. The filter media is positioned between the first endcap and the second endcap. The filter media creates a mechanical seal between at least one of the first endcap or the second endcap during rotation of the rotating filter cartridge without the use of a potting material. In at least one embodiment, the rotating filter cartridge further includes a body secured to the first endcap and the second endcap. At least one of the first endcap or the second endcap, and the body, may form a pocket that radially pinches the filter media to form the mechanical seal.

Abstract: An exhaust assembly includes a first tailpipe having an exit end and a curved portion along at least a portion of a length of the first tailpipe. The exhaust assembly further includes a baffle surrounding the first tailpipe at the exit end and defining a plurality of perforations therethrough. The exhaust assembly further includes a pair of shields. Each shield is attached to and at least partially surrounds each of the baffle and the first tailpipe. Each shield extends from a first end proximal to the exit end of the first tailpipe to a second end distal to the exit end of the first tailpipe. Each shield engages the baffle at the first end and engages the first tailpipe at least at or proximal to the second end. The pair of shields is adapted to allow fluid flow to or from the plurality of perforations of the baffle.

Abstract: A filter media holder for securing a filter media within a filter housing comprises a first grill plate having a plurality of first apertures defined therethrough, and a second grill plate having a plurality of second apertures defined therethrough. In a first configuration, the second grill plate is spaced apart from the first grill plate to allow a filter media to be disposed on the first grill plate or the second grill plate, and in a second configuration, the second grill plate is disposed proximate to the first grill plate such that the filter media is secured between the first grill plate and the second grill plate.

Abstract: Systems and methods described herein provide for assigning classifications to signals and corresponding messages for prioritization and transmission across a vehicle CAN bus. The assigned classifications are used to select authentication keys specific to each classification of message. Nodes of the CAN bus can include different sets of keys based on the classifications of messages handled at the nodes. Keys are distributed and localized to reduce any potential impact on critical functions of the vehicle system that may result from compromise of an authentication key.

Abstract: A high-temperature flow sensor includes strain relief wires for connecting cable wires to electrically resistive sensor elements to protect the sensor elements from fractures or other damage due to differences in thermal expansion and contraction of components. The resistive sensor material assembled with a support material is mounted in a tube with an electrically, conductive filler between the sensor material and the tube.

Abstract: A capacitive pressure transducer includes a shielded spacer positioned between the capacitor electrodes and driven with a separate voltage source.

Abstract: An address rotation system detects a trigger to initiate rotation of location information of an origin server that provides content to be served by a content delivery service. In response to the trigger, the address rotation system identifies an active networking route of the content delivery service and obtains, from the route, an assigned first name of the origin server and a first network address in a name service. The address rotation system replaces the first network address with a second network address and updates the name service to resolve a second name to the second network address. The address rotation system updates the content delivery service with the second name to allow the content delivery service to use the second name to obtain the second network address and access the origin server.