Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: Pant-like absorbent articles having handles on side panels of the article for ease of removal and donning of the absorbent garment and a method for forming is disclosed herein. The article includes a front waist region, a back waist region, and a chassis extending longitudinally between and interconnecting the front and back waist regions attached by at least one side panel. Formed within the side panel is at least one handle. The handle includes a slit formed through the side panel, the slit extending in both the longitudinal and lateral direction to provide a flap material. The flap material is folded towards the waist edge of the side panel to provide an aperture in the side panel.

Abstract: A communication device may receive an employee skill certification badge request for: (i) a first employee of an insurance enterprise, and (ii) a first employee skill category of a plurality of potential categories. Information about the received may be stored, and a badge server may gather and store data (e.g., quantitative and/or qualitative data) in an electronic evidence file based the first employee's interactions with customers during normal performance of his or her employment. A first manager of the first employee may be determined, and the badge server may receive from the first manager an indication that the electronic evidence file meets a threshold criteria. Responsive to the received indication, the badge server may associate the first employee with the first employee skill certification badge and transmit data to cause display of an icon associated with the first employee skill certification badge on other remote devices.

Abstract: A probe for use with a pulse oximeter apparatus is disclosed, as are a fixture for and a method of making the probe. The probe includes a housing and two fiber optic bundles. The first bundle has an emitter portion at one end, and is used for conducting light from a source thereof to the emitter portion from which the light is transmitted for transillumination through a body part. The second bundle is for conducting the transilluminated light incident upon a detector portion thereof to the pulse oximeter apparatus. The housing is overmolded onto the bundles so that the emitter and detector portions are securely positioned diametrically opposite each other across an opening defined by the housing. The overmolding makes the alignment of the emitter and detector portions largely impervious to movement of the body part when placed within the opening and thus between the emitter and detector portions.

Abstract: Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fc?-? transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL-2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL-2tm protein on the tumor cell surface membrane was confirmed by microscopy. RD995 cells transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H/HEN mice. Tumors of mice implanted with 106 or 105 RD995 cells transfected with IL-2tm grew slower than controls. It is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.

Abstract: A method of producing a mixture or solution of a liquid and a fusible solid comprises providing, in a container, the liquid and the fusible solid; and subjecting the container to a rotational motion about a first axis in a first direction while rotating the container about a second axis in a second direction to effect a dissolution of the fusible solid and a mixing of the components of the mixture or solution.

Abstract: A method of producing and simultaneously deaerating a mixture comprises providing, in a container, components of the mixture; and subjecting the container to a rotational motion about a first axis in a first direction while rotating the container about a second axis in a second direction to effect a mixing and a substantially simultaneous deaeration.

Abstract: A method of producing a mixture comprises providing, in a container, at least a first component of the mixture at a first temperature; adding a remaining component of the mixture to said at least a first component; subjecting the container to a rotational motion about a first axis in a first direction while rotating the container about a second axis in a second direction to effect a mixing; wherein the first temperature is lower than the temperature of the mixture at the end of the mixing.

Abstract: Apparatus and method for cutting an IOL optic from an IOL blank whereby the resultant IOL optic has a square edge and the cutting is performed in a combined linear and rotational cutting movement. In another aspect, an IOL optic is provided which includes a square edge and helically shaped striations formed therein to help reduce glare.

Abstract: Apparatus and method for cutting an IOL optic from an IOL blank whereby the resultant IOL optic has a square edge and the cutting is performed in a combined linear and rotational cutting movement. In another aspect, an IOL optic is provided which includes a square edge and helically shaped striations formed therein to help reduce glare.