Publication number: 20240262806
Abstract: The present invention relates to novel compounds of Formulae I-XI: wherein each A, A?, Q, Q?, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
Type:
Application
Filed:
August 24, 2022
Publication date:
August 8, 2024
Applicant:
PCT THERAPEUTICS, INC.
Inventors:
XIAOYAN ZHANG, TIANYI ZHENG, SCOTT j BARRAZA, LAUREN BEJCEK, BRADLEY B GILBERT, HUA GONG, HANDOKO HANDOKO, SEYEDMORTEZA HOSSEYNI, EDUARDO HUARTE, WOOHYUNG JEON, JING LI, YAO LIU, KYLE NIEDERER, MEENU PILLAI, ERICA N PARKER, ETTORE RASTELLI, NADIYA SYDORENKO, ANTHONY TURPOFF, MATTHEW G WOLL, NANJING ZHANG, YAN ZHANG, RAUFUL ALAM
