Abstract: The present disclosure provides systems and methods relating to the treatment of gastrointestinal dysmotility. In particular, the present disclosure provides systems and methods for delivering temporal patterns of electrical stimulation with respect to a refractory period to either suppress (e.g., treat hypermotility) or stimulate (e.g., treat hypomotility) contractions and motility in the gastrointestinal tract of a subject.

Abstract: The present disclosure relates to systems and methods for modulating gut motility. In particular, the present disclosure provides systems and methods for entraining interstitial cells of Cajal (ICCs) using patterns of electrical stimulation to increase gut motility. The systems and methods of ICC entrainment disclosed herein facilitate the treatment of various functional gastrointestinal disorders characterized by symptoms of dysmotility.

Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.