Abstract: A composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into shapes that are used to augment rotator cuff and acl repair. Sheets of bone fibers may be used as an interface between bone and tissue, tendons, and/or ligaments. The physical presence of the fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation. A delivery system and methods of use are also provided.

Abstract: A pharmaceutical composition for treating moderate or severe rosacea comprises a formulated, body weight-independent low dose of minocycline that reduces the severity of rosacea in at least 2 weeks with a decrease in lesion count, Investigator's Global Assessment (IGA) score, and Clinician's Erythema Assessment (CEA) score with a measured improvement in quality of life.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A method of repairing a chondral or osteochondral defect using an implant composition made of a plurality of demineralized bone fibers formed into a contiguous shape having a peg portion and a sheet portion to facilitate cartilage repair.

Abstract: A bone implant composition and methods thereof include bone material made into various implant shapes including a cylinder having an outermost layer and an inner layer completely surrounded by the outermost layer. The bone implant compositions and methods include a bag or cylindrical tube made from a bone material which may be filled with additional bone material.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

Abstract: A molecular imaging method for guidance in biopsy or surgical procedures includes selecting and inputting two different slant angles for stereotactic molecular imaging of a hot spot, positioning a patient to whom a radiotracer has been administered in a molecular imaging system including a solid-state gamma camera and a variable-angle square hole (VASH) collimator, acquiring two stereotactic molecular images with the VASH collimator, each of the two stereotactic molecular images being acquired when the VASH collimator is adjusted to a different one of the two different slant angles, calculating a 3D position of a hot spot, and performing a molecular image-guided biopsy procedure on the basis of the calculated 3D position. In acquiring the two stereotactic molecular images, the VASH collimator is positioned such that the two different slant angles are in a plane generally parallel (that is, within 30 degrees of parallel) to a coronal plane of the patient.

Abstract: A method for molecular image acquisition includes beginning acquisition of a molecular image via a molecular imaging system, performing one or more analyses of the molecular image during acquisition of the molecular image to determine whether at least one lesion is present in the image, and if it is determined that there is either at least one lesion present or there is not at least one lesion present in the image in any one of the one or more analyses of the molecular image, performing at least one of providing a recommendation that the acquisition be stopped or stopping the acquisition automatically.

Abstract: A composition for healing or improving skin includes a fabric or material impregnated with an oxygen generating material. The fabric may include a first side in contact with the skin for providing oxygen to the skin and a second side between the oxygen generating material and the air surrounding the skin to form a barrier for retaining heat and inhibiting evaporation.

Abstract: A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

Abstract: A molecular imaging method for guidance in biopsy or surgical procedures includes selecting and inputting two different slant angles for stereotactic molecular imaging of a hot spot, positioning a patient to whom a radiotracer has been administered in a molecular imaging system including a solid-state gamma camera and a variable-angle square hole (VASH) collimator, acquiring two stereotactic molecular images with the VASH collimator, each of the two stereotactic molecular images being acquired when the VASH collimator is adjusted to a different one of the two different slant angles, calculating a 3D position of a hot spot, and performing a molecular image-guided biopsy procedure on the basis of the calculated 3D position. In acquiring the two stereotactic molecular images, the VASH collimator is positioned such that the two different slant angles are in a plane generally parallel (that is, within 30 degrees of parallel) to a coronal plane of the patient.

Abstract: A method for molecular image acquisition includes beginning acquisition of a molecular image via a molecular imaging system, performing one or more analyses of the molecular image during acquisition of the molecular image to determine whether at least one hot spot is present in the image, and if it is determined that it is statistically significant that there is either at least one hot spot present or there is not at least one hot spot present in the image in any one of the one or more analyses of the molecular image, performing at least one of providing a recommendation that the acquisition be stopped or stopping the acquisition automatically.

Abstract: Compositions and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into shapes that are used to augment fixation of orthopedic implants and screws. Sheets of bone fibers may be used as an interface between bone and tissue, tendons, and/or ligaments. Cylindrical shaped implants that may be placed in drilled holes in bone prior to screw placement to enhance fixation of the screw. The physical presence of the fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the screw and hence fixation. The bone fiber compositions may be in the form of a cylinder or a tube. A delivery system and methods of use are also provided.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A method for molecular image acquisition includes beginning acquisition of a molecular image via a molecular imaging system, performing one or more analyses of the molecular image during acquisition of the molecular image to determine whether at least one hot spot is present in the image, and if it is determined that it is statistically significant that there is either at least one hot spot present or there is not at least one hot spot present in the image in any one of the one or more analyses of the molecular image, performing at least one of providing a recommendation that the acquisition be stopped or stopping the acquisition automatically.

Abstract: A molecular imaging method for guidance in biopsy or surgical procedures includes selecting and inputting two different slant angles for stereotactic molecular imaging of a hot spot, positioning a patient to whom a radiotracer has been administered in a molecular imaging system including a solid-state gamma camera and a variable-angle square hole (VASH) collimator, acquiring two stereotactic molecular images with the VASH collimator, each of the two stereotactic molecular images being acquired when the VASH collimator is adjusted to a different one of the two different slant angles, calculating a 3D position of a hot spot, and performing a molecular image-guided biopsy procedure on the basis of the calculated 3D position. In acquiring the two stereotactic molecular images, the VASH collimator is positioned such that the two different slant angles are in a plane generally parallel (that is, within 30 degrees of parallel) to a coronal plane of the patient.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.