Patents by Inventor Bradley J. Molyneaux

Bradley J. Molyneaux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPAK kinase inhibitors as neuroprotective agents
    Patent number: 11414379
    Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: August 16, 2022
    Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH OF HIGHER EDUCATION, XIAMAN UNIVERSITY, UNIVERSITY OF EXETER
    Inventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
  • SPAK KINASE INHIBITORS AS NEUROPROTECTIVE AGENTS
    Publication number: 20210261497
    Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: February 16, 2021
    Publication date: August 26, 2021
    Inventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
  • SPAK kinase inhibitors as neuroprotective agents
    Patent number: 10995061
    Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: May 4, 2021
    Assignees: United States Government as Represented by the Department of Veterans Affairs, The University of Pittsburgh—of the Commonwealth of Higher Education, Xiamen University, University of Exeter
    Inventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
  • SPAK KINASE INHIBITORS AS NEUROPROTECTIVE AGENTS
    Publication number: 20200102266
    Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: September 30, 2019
    Publication date: April 2, 2020
    Inventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
  • METHODS AND COMPOSITIONS RELATING TO NEURONAL CELL AND TISSUE DIFFERENTIATION
    Publication number: 20120251506
    Abstract: The invention relates to methods for isolating and purifying specific types of neurons, such as cortical or other projection neurons including corticospinal motor neurons, subcerebral projection neurons, and callosal projection neurons. The invention also relates to genes that are specific for particular neuronal subtypes, and the use of such genes in genetic/molecular control of cell development. The isolated cells and subtype-specific genes also have uses in diagnostics, therapeutics, and screening assays for pharmaceutical molecules.
    Type: Application
    Filed: May 18, 2012
    Publication date: October 4, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Jeffrey D. Macklis, Paola Arlotta, Bradley J. Molyneaux
  • METHODS AND COMPOSITIONS RELATING TO NEURONAL CELL AND TISSUE DIFFERENTIATION
    Publication number: 20120020929
    Abstract: The invention relates to methods for isolating and purifying specific types of neurons, such as cortical or other projection neurons including corticospinal motor neurons, subcerebral projection neurons, and callosal projection neurons. The invention also relates to genes that are specific for particular neuronal subtypes, and the use of such genes in genetic/molecular control of cell development. The isolated cells and subtype-specific genes also have uses in diagnostics, therapeutics, and screening assays for pharmaceutical molecules.
    Type: Application
    Filed: January 19, 2011
    Publication date: January 26, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Jeffrey D. Macklis, Paola Arlotta, Bradley J. Molyneaux