Patents by Inventor Bradley J. Newhouse

Bradley J. Newhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PI3K inhibitors
    Patent number: 12281122
    Abstract: A compound having the following structure of Formula (I): or a stereoisomer of the compound, tautomer of the compound, pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, A, X, Z, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.
    Type: Grant
    Filed: August 5, 2024
    Date of Patent: April 22, 2025
    Assignee: COGENT BIOSCIENCES, INC.
    Inventors: Payal Chatterjee, Mark J. Chicarelli, Michael L. Conner, John Fischer, Jennifer Fulton, Ravi Kumar Jalluri, Hailey J. Knox, Vijay Kumar, Bradley J. Newhouse, Martha E. Rodriguez, Leah J. Salituro, Aaron C. Smith, Lee M. Stunkard, Yeyun Zhou, Paul R. Carlson, Scott W. Niman, Patrick J. Sutter, John I. Trujillo, Logan E. Vine, Brooklynn Venteicher
  • COMPOUNDS FOR FGFR INHIBITION
    Publication number: 20250066352
    Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.
    Type: Application
    Filed: August 19, 2024
    Publication date: February 27, 2025
    Inventors: Jay Bradford Fell, John E. Robinson, John P. Fischer, Logan E. Vine, Martha E. Rodriguez, Jennifer Fulton, Tanna Bettendorf, Bradley J. Newhouse, Robert A. Rieger, Cori A. Malinky, Aaron Christopher Smith, Ravi Kumar Jalluri, Mark Joseph Chicarelli, Leah J. Salituro, Macedonio J. Mejia
  • COMPOUNDS FOR FGFRS INHIBITORS
    Publication number: 20240270741
    Abstract: A compound having the following structure of Formula (I): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R5, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.
    Type: Application
    Filed: January 9, 2024
    Publication date: August 15, 2024
    Inventors: Jay Bradford Fell, John E. Robinson, John P. Fischer, Logan E. Vine, Martha E. Rodriguez, Jennifer Fulton, Tanna Bettendorf, Bradley J. Newhouse, Robert A. Rieger, Cori A. Malinky, Aaron Christopher Smith, Toya D. Scaggs, Joshua Dahlke, Ravi Kumar Jalluri, Mark Joseph Chicarelli, Leah J. Salituro, Macedonio J. Mejia, Payal Chatterjee
  • KRAS G12D INHIBITORS
    Publication number: 20240034733
    Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 1, 2024
    Inventors: Matthew Arnold Marx, John David Lawson, Patrick Michael Doerner Barbaur, James Francis Blake, Jay Bradford Fell, John Peter Fischer, Bradley J. Newhouse, Phong Nguyen, Jacob M. O'Leary, Spencer Pajk, Martha E. Rodriguez, Tony Pisal Tang
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 7176229
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: February 13, 2007
    Assignee: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence Edward Burgess, John Joseph Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 6998416
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: February 14, 2006
    Assignee: Icos Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Publication number: 20040152754
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Application
    Filed: January 15, 2004
    Publication date: August 5, 2004
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
  • Cyclic AMP-specific phosphodie sterase inhibitors
    Patent number: 6716871
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: April 6, 2004
    Assignee: Icos Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E Burgess, John J. Gaudino, Zachary S Jones, Bradley J Newhouse, Stephen T. Schlachter
  • CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS
    Publication number: 20040023945
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Application
    Filed: May 17, 2002
    Publication date: February 5, 2004
    Applicant: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 6458787
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: October 1, 2002
    Assignee: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlacter
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 6423710
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: July 23, 2002
    Assignee: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 6258833
    Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: July 10, 2001
    Assignee: ICOS Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward Kesicki, Amy Oliver, Laurence E. Burgess, John J. Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlacter