Abstract: Three-dimensional (3D) bioprinting has tremendous potential to aid in the creation of engineered tissues and organs that are so desperately in need. In this disclosure, a new type of bio-ink for 3D bioprinting made of sheared slurries of biomaterial hydrogel, in particular alginate hydrogel having micro-capillary structure (Capgel), in particular Capgel having increased stackability and thus self-assembly capability through the formation of a polyelectrolyte complex “skin” on the outer surfaces of the Capgel block with poly-L-lysine (PLL) coating prior to printing needle extrusion is provided as injectable biomaterial tissue scaffolding system, so that such stackable structure as weave patterns and cylindrical structures can be successfully printed with the new Capgel bio-ink. Further, the micro-capillary structure inherent in the original Capgel blocks is retained in the printed bio-ink making up the larger 3D structures and allows for cell culture in it.

Abstract: Biologic interfacial tissue-engineered systems (BITES) disclosed here is a biomaterial platform to provide engineered human and/or animal skin-like constructs for study of biting and/or blood feeding behavior of mosquitoes as well as other insects and arthropods. Provided herein are use and methods of making for BITES, in particular use and methods of cellularized Capgel for BITES with human cells.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Abstract: Apparatus and methods for blocking needle tracts are disclosed. In some embodiments, the needle tracts are blocked by using a needle that includes an elongated shaft that defines an outer surface, and a polymer coating applied to the outer surface of the shaft, the coating being adapted to block the tract formed by insertion of the needle into an object.

Abstract: Apparatus and methods for blocking needle tracts are disclosed. In some embodiments, the needle tracts are blocked by using a needle that includes an elongated shaft that defines an outer surface, and a polymer coating applied to the outer surface of the shaft, the coating being adapted to block the tract formed by insertion of the needle into an object.

Abstract: The present invention provides copper capillary alginate gels stabilized with barium, chitosan, its derivates, or a combination thereof. These stabilized gels are useful as scaffolds for containing, growing, or regenerating biological agents and cells for in vivo or in vitro use.