Patents by Inventor Bradley John HEDBERG

Bradley John HEDBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20230390354
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: February 21, 2023
    Publication date: December 7, 2023
    Applicant: ZYMEWORKS BC INC.
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 11617777
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 4, 2023
    Inventors: Geoffrey C. Winters, Alexander Laurence Mandel, James R. Rich, Bradley John Hedberg, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, John Babcook
  • ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20220288203
    Abstract: The present invention is directed to anti-podocalyxin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of cancer.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 15, 2022
    Inventors: Kelley Marshall MCNAGNY, Calvin D. ROSKELLEY, Michael R. HUGHES, Diana CANALS HERNAEZ, Klas Ola BLIXT, John Stephen BABCOOK, Christopher John BOND, Ismael SAMUDIO, Jan Peter BERGQVIST, Katherine Grace MACDONALD, Anna VON ROSSUM, Bradley John HEDBERG, Pamela Megan DEAN
  • Anti-podocalyxin antibodies and methods of using the same
    Patent number: 11390673
    Abstract: The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated Ab1 and 3G2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said anti bodies for targeting tumour endothelial cells that express podocalyxin.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: July 19, 2022
    Inventors: John Stephen Babcook, Kelly Marshall McNagny, Calvin D. Roskelley, Bradley John Hedberg, Kimberly Ashely Snyder, Michael R. Hughes
  • Anti-podocalyxin antibodies and methods of using the same
    Patent number: 11090383
    Abstract: The present invention is directed to anti-podocalyxin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of cancer.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: August 17, 2021
    Inventors: Kelly Marshall McNagny, Calvin D. Roskelley, Michael R. Hughes, Diana Canals Hernaez, Klas Ola Blixt, John Stephen Babcook, Christopher John Bond, Ismael Samudio, Jan Peter Bergqvist, Katherine Grace MacDonald, Anna Von Rossum, Bradley John Hedberg, Pamela Megan Dean
  • ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20190367606
    Abstract: The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated Ab1 and 3G2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said antibodies for targeting tumour endothelial cells that express podocalyxin.
    Type: Application
    Filed: August 12, 2019
    Publication date: December 5, 2019
    Inventors: John Stephen BABCOOK, Kelly Marshall MCNAGNY, Calvin D. ROSKELLEY, Bradley John HEDBERG, Kimberly Ashely SNYDER, Michael R. HUGHES
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20190269785
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: February 11, 2019
    Publication date: September 5, 2019
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10201614
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 12, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, Alexander Laurence Mandel, James R. Rich, Bradley John Hedberg, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, John Babcook
  • ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20180296673
    Abstract: The present invention is directed to anti-podocalyxin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of cancer.
    Type: Application
    Filed: September 30, 2016
    Publication date: October 18, 2018
    Inventors: Kelly Marshall MCNAGNY, Calvin D. ROSKELLEY, Michael R. HUGHES, Diana Canals HERNAEZ, Klas Ola BLIXT, John Stephen BABCOOK, Christopher John BOND, Ismael SAMUDIO, Jan Peter BERGQVIST, Katherine Grace MACDONALD, Anna VON ROSSUM, Bradley John HEDBERG
  • ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20160264663
    Abstract: The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated Ab1 and 3G2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said antibodies for targeting tumour endothelial cells that express podocalyxin.
    Type: Application
    Filed: October 21, 2014
    Publication date: September 15, 2016
    Inventors: John Stephen BABCOOK, Kelly Marshall MCNAGNY, Calvin D. ROSKELLEY, Bradley John HEDBERG, Kimberly Ashely SNYDER, Michael R. HUGHES
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20160038606
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Geoffrey C. WINTERS, Alexander Laurence MANDEL, James R. RICH, Bradley John HEDBERG, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, John BABCOOK