Abstract: In one embodiment an analyte monitoring system is disclosed. The system includes a body worn device having a housing that contains a processor, a memory, a power supply and a sensor interface. The system further includes an analyte sensor that is coupled to the sensor interface. The analyte sensor has a proximal portion contained within the housing that is interfaced with the sensor interface. The analyte sensor also has a distal portion configured to be inserted into a host when positioned outside the housing. The system also includes a finite state machine that selects from possible sensor calibration coefficients based on a current state of the analyte monitoring system, an initial input, and longitudinal inputs received from the analyte sensor. Wherein the processor generates calibrated sensor values based on the selected calibration coefficients and longitudinal inputs from the analyte sensor.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: In one embodiment, a sensor to measure the presence of an analyte is disclosed. The sensor includes a working conductor with an electrode reactive surface. The sensor further includes a first reactive chemistry that is responsive to a first analyte and is in direct contact with the electrode reactive surface. The first reactive chemistry includes an enzyme, a first transport material, and an entrappable cofactor that includes a cofactor for the enzyme coupled to an anchor molecule. The sensor further includes a second transport material that enables diffusion of the first analyte to the first reactive chemistry.

Abstract: An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Abstract: In one embodiment, a working electrode measuring the presence of a first analyte is disclosed. The working electrode includes a working conductor that has a first electrode reactive surface. The working electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Additionally, a first reactive chemistry that is responsive to the first analyte is included in the working electrode. The first reactive chemistry includes a mediator, an enzyme and a cofactor. Wherein the first reactive chemistry is located between the working conductor and the first transport material.

Abstract: A working electrode measuring the presence of an analyte is described as one embodiment. The working electrode includes a working conductor with a reactive surface that is operated at a first potential. The working electrode further includes a first transport material with properties that enable analyte flux to the reactive surface. Additionally, the working electrode has a second transport material with properties that enable reactant flux to the reactive surface, wherein the analyte flux and the reactant flux are in dissimilar directions.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: An apparatus for early detection of sepsis in a host is disclosed. The apparatus includes a first sensor to directly measure a glucose level, a second sensor to directly measure a lactate level and a third sensor to directly measure a tissue oxygen level. The first sensor, the second sensor, and the third sensor all being inserted at a single point of entry in a subcutaneous space of the host such that a predetermined correlation between the glucose level, lactate level, and tissue oxygen level signals conditions related to sepsis.

Abstract: An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Abstract: Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Abstract: An apparatus for early detection of sepsis in a host is disclosed. The apparatus includes a first sensor to directly measure a glucose level, a second sensor to directly measure a lactate level and a third sensor to directly measure a tissue oxygen level. The first sensor, the second sensor, and the third sensor all being inserted at a single point of entry in a subcutaneous space of the host such that a predetermined correlation between the glucose level, lactate level, and tissue oxygen level signals conditions related to sepsis.

Abstract: A working electrode measuring the presence of an analyte is described as one embodiment. The working electrode includes a working conductor with a reactive surface that is operated at a first potential. The working electrode further includes a first transport material with properties that enable analyte flux to the reactive surface. Additionally, the working electrode has a second transport material with properties that enable reactant flux to the reactive surface, wherein the analyte flux and the reactant flux are in dissimilar directions.

Abstract: Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Abstract: Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor signal values and reference readings may be used to estimate a relationship between sensor signal values and measurements of blood glucose concentration.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.