Patents by Inventor Bradley M. Holmes

Bradley M. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sugar extraction and ionic liquid recycling using alkaline solutions
    Patent number: 10358685
    Abstract: The present invention provides a method for obtaining a monosaccharide from a lignocellulosic material in a form suitable for use as a carbon source in a reaction. In some embodiments, the monosaccharide is in a form suitable for use in a fermentation reaction, e.g., to produce an alcohol such as ethanol.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: July 23, 2019
    Assignees: The Regents of the University of California, National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Ning Sun, Bradley M. Holmes, Kim Tran, Anthe George, Blake Simmons
  • Thermostable cellulases, and mutants thereof, capable of hydrolyzing cellulose in ionic liquid
    Patent number: 9322042
    Abstract: The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introducing a thermostable cellulase to the solution, such that the cellulose is hydrolyzed by the cellulase. The present invention also provides for a Thermatoga maritima thermostable cellulase mutant with increased cellulase activity.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: April 26, 2016
    Assignees: The Regents of the University of California, Sandia Corporation
    Inventors: Rajat Sapra, Supratim Datta, Zhiwei Chen, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
  • Recovery of sugars from ionic liquid biomass liquor by solvent extraction
    Patent number: 9157130
    Abstract: The present invention provides for a composition comprising a solution comprising (a) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase and (b) an organic phase, wherein the solution comprises a sugar and a boronic acid. The present invention also provides for a method of removing a sugar from a solution, comprising: (a) providing a solution comprising (i) an IL or ILA phase and (ii) an organic phase, wherein the solution comprises an IL, a sugar and a boronic acid; (b) contacting the sugar with the boronic acid to form a sugar-boronic acid complex, (c) separating the organic phase and the aqueous phase, wherein the organic phase contains the sugar-boronic acid complex, and optionally (d) separating the sugar from the organic phase.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: October 13, 2015
    Assignees: Sandia Corporation, The Regents of the University of California
    Inventors: Timothy Charles R. Brennan, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
  • SUGAR EXTRACTION AND IONIC LIQUID RECYCLING USING ALKALINE SOLUTIONS
    Publication number: 20150122246
    Abstract: The present invention provides a method for obtaining a monosaccharide from a lignocellulosic material in a form suitable for use as a carbon source in a reaction. In some embodiments, the monosaccharide is in a form suitable for use in a fermentation reaction, e.g., to produce an alcohol such as ethanol.
    Type: Application
    Filed: May 2, 2013
    Publication date: May 7, 2015
    Inventors: Ning Sun, Bradley M. Holmes, Kim Tran, Anthe George, Blake Simmons
  • Recovery of sugars from ionic liquid biomass liquor by solvent extraction
    Publication number: 20120315695
    Abstract: The present invention provides for a composition comprising a solution comprising (a) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase and (b) an organic phase, wherein the solution comprises a sugar and a boronic acid. The present invention also provides for a method of removing a sugar from a solution, comprising: (a) providing a solution comprising (i) an IL or ILA phase and (ii) an organic phase, wherein the solution comprises an IL, a sugar and a boronic acid; (b) contacting the sugar with the boronic acid to form a sugar-boronic acid complex, (c) separating the organic phase and the aqueous phase, wherein the organic phase contains the sugar-boronic acid complex, and optionally (d) separating the sugar from the organic phase.
    Type: Application
    Filed: March 29, 2012
    Publication date: December 13, 2012
    Applicants: SANDIA CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Timothy Charles R. Brennan, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
  • Novel method of acid hydrolysis of biomass and the recovery of sugars thereof by solvent extraction
    Publication number: 20120301948
    Abstract: The present invention provides for a method of hydrolyzing a cellulose, hemicellulose, or ligno-cellulose comprising: (a) contacting (i) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase comprising cellulose, hemicellulose, or ligno-cellulose, or a mixture thereof, and (ii) an acid, such that the cellulose, hemicellulose, or ligno-cellulose is hydrolyzed into sugar, and (b) optionally adding water to the IL or ILA phase wherein the proportion of water in the IL or ILA phase does not exceed about 60% by weight. The present invention also provides for a method of recovering a sugar comprising contacting an IL or ILA phase and an organic phase comprising an organic acid.
    Type: Application
    Filed: March 30, 2012
    Publication date: November 29, 2012
    Applicants: SANDIA CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Timothy Charles R. Brennan, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
  • THERMOSTABLE CELLULASES, AND MUTANTS THEREOF, CAPABLE OF HYDROLYZING CELLULOSE IN IONIC LIQUID
    Publication number: 20120129227
    Abstract: The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introducing a thermostable cellulase to the solution, such that the cellulose is hydrolyzed by the cellulase. The present invention also provides for a Thermatoga maritima thermostable cellulase mutant with increased cellulase activity.
    Type: Application
    Filed: April 23, 2010
    Publication date: May 24, 2012
    Applicants: Sandia Corporation, The Regents of the University of California
    Inventors: Rajat Sapra, Supratim Datta, Zhiwei Chen, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch