Abstract: The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.

Abstract: A bi-directional voltage converter with a current-sensing circuit includes a first sub-circuit including a high-voltage terminal, a first switching device, and a first primary winding of a first transformer; a second sub-circuit including a second switching device, a second primary winding of a second transformer, and ground; a low-voltage terminal connected, via an inductor, to a point between the first the second sub-circuits; a third switching device connected to a first secondary winding of the first transformer; a fourth switching device connected to a second secondary winding of the second transformer; and a control circuit configured to control the switching devices. The third and fourth switching devices are included in the current-sensing circuit and are connected to a current-sense terminal, and the current-sensing circuit generates a voltage waveform at the current-sense terminal representing a current flowing through at least one of the first and the second switching devices.

Abstract: A measuring and diluting cup for preparing pharmaceutical doses is provided. The cup comprises an upstanding body having an open mouth and a hollow interior bounded by a sidewall. The cup also has a pharmaceutical measuring compartment. The pharmaceutical measuring compartment is opposite the open mouth and forms a bottom of the hollow interior. The cup also has a diluent measuring compartment which is adjacent the open mouth. The pharmaceutical measuring compartment captures a measured volume smaller than the volume of the diluent measuring compartment, and the pharmaceutical measuring compartment opens to the diluent measuring compartment. The upstanding body is substantially cylindrical and the pharmaceutical measuring compartment has a cylindrical or conical region concentric with the upstanding body. The pharmaceutical measuring compartment has a smaller diameter than the upstanding body.