Abstract: An example ceramic panel has a first surface and a second surface. The ceramic panel has a bond finger well on the first surface of the ceramic panel a scribe line well on the second surface of the ceramic panel. The ceramic panel also has a scribe line along the scribe line well.

Abstract: An example includes: a substrate having a first package surface, having a second package surface opposite the first package surface, and having a die cavity with a depth extending into the first package surface; a semiconductor die having bond pads on a first die surface and having a second die surface opposite the first die surface, the semiconductor die having a die thickness, the second die surface of the semiconductor die mounted in the die cavity; a cover over a portion of the first die surface; conductors coupling the bond pads of the semiconductor die to bond fingers on the first package surface of the substrate; and dielectric material over the conductors, the bond fingers, the bond pads, at least a portion of the first semiconductor die and at least a portion of the cover, wherein the dielectric material extends above the first package surface of the substrate.

Abstract: An example ceramic panel has a first surface and a second surface. The ceramic panel has a bond finger well on the first surface of the ceramic panel a scribe line well on the second surface of the ceramic panel. The ceramic panel also has a scribe line along the scribe line well.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: The present application generally relates to identifying gene clusters from long-read genomic sequencing data. The disclosure provides methods, non-transitory computer readable media, and apparatuses for processing long-read genomic sequencing data, performing error corrections, and identifying gene cluster, e.g. biosynthetic gene clusters. The methods, non-transitory computer readable media, and apparatuses described herein can be employed in broad areas of biological applications, such as drug discovery, industrial chemical discovery and production, and basic biological research.

Abstract: A method for estimating at least one ring-related parameter related to at least one piston ring may include estimating a bore distortion of a cylinder bore. The bore distortion may include a plurality of bore distortions corresponding to a plurality of respective piston locations within the cylinder bore. The method may also include receiving the bore distortion in a ring performance model configured to dynamically estimate a plurality of ring-related parameters associated with combustion in the cylinder bore during operation of the internal combustion engine. The ring performance model may be configured to receive a static data signal indicative of static parameters and a dynamic data signal indicative of dynamic parameters related to operation of the internal combustion engine. The ring performance model may be configured to estimate at least one ring-related parameter related to at least one piston ring during operation of the internal combustion engine.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A piston for an internal combustion engine includes a plurality of valve pockets formed in a piston rim, the valve pockets forming fluid flow paths through the piston rim. Each of the valve pockets includes a central step standing proud of a pocket floor to limit a fluid flow area through the pocket and slow combustion gas flow from a combustion bowl toward a cylinder liner and thereby reduce displacement of an engine oil film thereon.

Abstract: An example includes: a substrate having a first package surface, having a second package surface opposite the first package surface, and having a die cavity with a depth extending into the first package surface; a semiconductor die having bond pads on a first die surface and having a second die surface opposite the first die surface, the semiconductor die having a die thickness, the second die surface of the semiconductor die mounted in the die cavity; a cover over a portion of the first die surface; conductors coupling the bond pads of the semiconductor die to bond fingers on the first package surface of the substrate; and dielectric material over the conductors, the bond fingers, the bond pads, at least a portion of the first semiconductor die and at least a portion of the cover, wherein the dielectric material extends above the first package surface of the substrate.

Abstract: An example ceramic panel has a first surface and a second surface. The ceramic panel has a bond finger well on the first surface of the ceramic panel a scribe line well on the second surface of the ceramic panel. The ceramic panel also has a scribe line along the scribe line well.

Abstract: A piston for an internal combustion engine includes a piston crown and a piston skirt, and an oil gallery formed between the piston crown and the piston skirt. A gallery inlet to the oil gallery, and a plurality of gallery drain outlets are formed in the piston skirt. The gallery drain outlets have, circumferentially around the piston center axis, a non-axisymmetric arrangement in a distribution biased to an anti-thrust side of the piston.

Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A method for estimating at least one ring-related parameter related to at least one piston ring may include estimating a bore distortion of a cylinder bore. The bore distortion may include a plurality of bore distortions corresponding to a plurality of respective piston locations within the cylinder bore. The method may also include receiving the bore distortion in a ring performance model configured to dynamically estimate a plurality of ring-related parameters associated with combustion in the cylinder bore during operation of the internal combustion engine. The ring performance model may be configured to receive a static data signal indicative of static parameters and a dynamic data signal indicative of dynamic parameters related to operation of the internal combustion engine. The ring performance model may be configured to estimate at least one ring-related parameter related to at least one piston ring during operation of the internal combustion engine.

Abstract: A piston for an internal combustion engine includes a plurality of valve pockets formed in a piston rim, the valve pockets forming fluid flow paths through the piston rim. Each of the valve pockets includes a central step standing proud of a pocket floor to limit a fluid flow area through the pocket and slow combustion gas flow from a combustion bowl toward a cylinder liner and thereby reduce displacement of an engine oil film thereon.

Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.

Abstract: A piston-connecting rod assembly for an internal combustion engine includes a piston pivotally mated to a connecting rod by a piston pin. The piston pin includes a first pin end, a second pin end, and a midsection. When assembled, the first pin end and second pin end are respectively received in a first pin bore and second pin on the piston while the midsection is accommodated in a cross-bore through the connecting rod. The piston pin may include a wear resistant layer applied over at least a portion of its external surface that may include at least one of tungsten disulfide and molybdenum disulfide. The wear resistant layer may be applied as part of a manufacturing process performed on the piston pin.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising sing a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.