Patents by Inventor Bradley P. Kropp

Bradley P. Kropp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue graft compositions and methods for producing same
    Patent number: 8974810
    Abstract: A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: March 10, 2015
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Bradley P. Kropp, Hsueh-Kung Lin, Fadee Mandelek, Brian P. Grady
  • In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    Publication number: 20090304645
    Abstract: A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 10, 2009
    Inventors: Bradley P. Kropp, Earl Y. Cheng, Yuan Yuan Zhang, Rick Cowan, Peter Moore
  • Urinary tract tissue graft compositions and methods for producing same
    Patent number: 7507422
    Abstract: A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The distal ileal segment of small intestinal submucosa may be utilized as an unseeded tissue graft composition, or the distal ileal segment of small intestinal submucosa may be positioned in a tissue culture frame, and smooth muscle and urothelial cells isolated from a tissue specimen of a subject and cultured are then seeded upon the distal ileal segment of small intestinal submucosa, thereby forming a urinary tract tissue graft.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: March 24, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Bradley P. Kropp, Yuan Yuan Zhang, Earl Y. Cheng, Hsueh-Kung Lin, Rick Cowan
  • Vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    Patent number: 7122200
    Abstract: A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: October 17, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Bradley P. Kropp, Earl Y. Cheng, Yuan Yuan Zhang, Rick Cowan, Peter Moore
  • Urinary tract tissue graft compositions and methods for producing same
    Patent number: 7078033
    Abstract: A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The distal ileal segment of small intestinal submucosa may be utilized as an unseeded tissue graft composition, or the distal ileal segment of small intestinal submucosa may be positioned in a tissue culture frame, and smooth muscle and urothelial cells isolated from a tissue specimen of a subject and cultured are then seeded upon the distal ileal segment of small intestinal submucosa, thereby forming a urinary tract tissue graft.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: July 18, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Bradley P. Kropp, Yuan Yuan Zhang, Earl Y. Cheng, Hsueh-Kung Lin, Rick Cowan
  • Urinary tract tissue graft compositions and methods for producing same
    Publication number: 20030165474
    Abstract: A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The distal ileal segment of small intestinal submucosa may be utilized as an unseeded tissue graft composition, or the distal ileal segment of small intestinal submucosa may be positioned in a tissue culture frame, and smooth muscle and urothelial cells isolated from a tissue specimen of a subject and cultured are then seeded upon the distal ileal segment of small intestinal submucosa, thereby forming a urinary tract tissue graft.
    Type: Application
    Filed: December 6, 2002
    Publication date: September 4, 2003
    Inventors: Bradley P. Kropp, Yuan Yuan Zhang, Earl Y. Cheng, H.K. Lin, Rick Cowan
  • In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    Publication number: 20020087214
    Abstract: A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.
    Type: Application
    Filed: December 10, 2001
    Publication date: July 4, 2002
    Inventors: Bradley P. Kropp, Earl Y. Cheng, Yuan Yuan Zhang, Rick Cowan, Peter Moore