Abstract: It was found that DUXC family proteins were efficient activators of EGA and that DUXC proteins could be used in methods in the reprogramming of cells to a totipotent state and to increase the efficiency of somatic cell nuclear transfer (SCNT). Accordingly, aspects of the disclosure relate to a method for reprogramming a cell into a totipotent state, the method comprising expressing a DUXC family protein in the cell. Further aspects of the disclosure relate to a method for making a host cell nuclear transfer (SCNT) embryo comprising expressing a DUXC protein in a somatic cell and transferring the nucleus of the somatic cell to an enucleated oocyte, thereby making a SCNT embryo.

Abstract: Methods, systems, and diagnostic tests, including test kits for assessing an offspring's risk of developing a disease or condition known or suspected to have a causal or contributing relationship to an age related epigenetic event in a paternal germ line are disclosed and described.

Abstract: Methods, systems, and diagnostic tests, including test kits for assessing an offspring's risk of developing a disease or condition known or suspected to have a causal or contributing relationship to an age related epigenetic event in a paternal germ line are disclosed and described