Abstract: A glove device for employment in the communication of medications, lubricants, or other substances is described, which is particularly useful in communicating such substances to in vivo treatment areas, such as the prostate or rectum. The glove device is preferably embodied in a substantially tactile, smooth and disposable material which contains a substance communication pathway embedded within that permits substance communication from a substance containing reservoir to an in vivo treatment site. The glove device may regulate the substance communication and may transmit greater than one substance simultaneously and in succession without removing the invention from a treatment site.