Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

Abstract: The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware and specific imaging conditions in the imaging system that variably affect camera output. The present invention determines the compensation factor based on assessing the output of the camera against a known light source for a specific set of imaging conditions in the imaging system. The compensation factor is then stored in memory corresponding to the specific set of imaging conditions. Upon subsequent imaging with the set of imaging conditions, the corresponding compensation factor is called from memory and applied to the camera output. A compensation factor may be determined and stored for each hardware state and imaging condition available to the imaging system.

Abstract: A wood-type golf club head (40) having a major body (50), a striking plate insert (55) and a minor body (60) is disclosed herein. The major body (50) is composed of a metal material and has a front wall section (72), a return section (74), a sole section (76), a ribbon section (78) and a ledge portion (80). The minor body (50) is preferably composed of a low density material and has a crown section (62) and a ribbon section (64). The striking plate insert (55) is composed of a metal material. An epoxy-based composition (200) is placed at a face-sole junction (205) to lower the amplitude of the sound of the golf club head (40) during impact with a golf ball.

Abstract: A wood-type golf club head (40) having a major body (50), a striking plate insert (55) and a minor body (60) is disclosed herein. The major body (50) is composed of a metal material and has a front wall section (72), a return section (74), a sole section (76), a ribbon section (78) and a ledge portion (80). The minor body (50) is preferably composed of a low density material and has a crown section (62) and a ribbon section (64). The striking plate insert (55) is composed of a metal material. An epoxy-based composition (200) is placed at a face-sole junction (205) to lower the amplitude of the sound of the golf club head (40) during impact with a golf ball.

Abstract: The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.

Abstract: An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. The body further includes a view port enabling viewing of the sample contained in the interior cavity. A door is mounted to the body that is movable between an opened condition, enabling access to the interior cavity through the cavity opening, and a closed condition, positioning a door rear portion substantially adjacent the body front portion to prevent access through the cavity opening. The box assembly further includes a moveable stage disposed in the cavity interior that supports the sample. The moveable stage is adapted to selectively position the sample at a selected one of a plurality of positions relative to the view hole.

Abstract: An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. A door is mounted to the body that is movable between an opened condition, enabling access to the interior cavity through the cavity opening, and a closed condition, positioning a door rear portion substantially adjacent the body front portion to prevent access through the cavity opening. The box assembly further includes a compressible light-tight seal material disposed on one of the rear portion and the front portion, and a securing device disposed between the body front portion and the door rear portion. In the closed condition, the securing device generates a securing force between the door and the body sufficient to substantially uniformly compress at least a portion of the compressible material to form a light-tight seal about the opening into the interior cavity.

Abstract: An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. The body further includes a view hole enabling viewing of the sample contained in the interior cavity. A door is mounted to the body that is movable between an opened condition, enabling access to the interior cavity through the cavity opening, and a closed condition, positioning a door rear portion substantially adjacent the body front portion to prevent access through the cavity opening. The box assembly further includes an optical filter select device to selectively position one of a plurality of optical filters between the sample and the view hole to intersect light from the sample.

Abstract: The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

Abstract: Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a substantial portion of light emitted from the animal from escaping the chamber when the chamber is closed and the animal is inside the chamber and a light monitoring device for collecting light from different portions of the animal when the animal is inside the closed chamber. The light monitoring device is arranged to collect light over substantially the entire surface area of the body and head of the animal, and the light monitoring device generates a quantified value based on the light collected from the animal. The animal does not have to be under anesthesia.

Abstract: The invention describes systems and methods for calibrating a low-level light imaging system. Techniques described herein employ a light calibration device that is placed within a low level light imaging box to calibrate the system and its constituent components such as the camera and processing system. The calibration device comprises an array of low-power light supplies each having a known emission. By taking an image of each low-power light supply, and comparing the processed result with the known emission, the accuracy of the imaging system and its absolute imaging characteristics may be assessed and verified.

Abstract: The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at least partially resemble the optical behavior of mammalian tissue. Imaging the light source or phantom device may incorporate known properties of the optically selective material. Testing methods described herein assess the performance of a low-level light imaging system (such as the software) by processing light output by the phantom device and comparing the output against known results. The assessment builds a digital representation of the light source or test device and compares one or more components of the digital representation against one or more known properties for the light source or the test device.

Abstract: The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions pertinent to in vivo light imaging: investigation and control of three-dimensional imaging data and reconstruction algorithms; control of topographic reconstruction algorithms; tomographic spectral imaging and analysis; and comparison of two-dimensional or three-dimensional imaging data obtained at different times.

Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

Abstract: An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.

Abstract: The invention describes systems and methods for calibrating a low-level light imaging system. Techniques described herein employ a light calibration device that is placed within a low level light imaging box to calibrate the system and its constituent components such as the camera and processing system. The calibration device comprises an array of low-power light supplies each having a known emission. By taking an image of each low-power light supply, and comparing the processed result with the known emission, the accuracy of the imaging system and its absolute imaging characteristics may be assessed and verified.

Abstract: The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware and specific imaging conditions in the imaging system that variably affect camera output. The present invention determines the compensation factor based on assessing the output of the camera against a known light source for a specific set of imaging conditions in the imaging system. The compensation factor is then stored in memory corresponding to the specific set of imaging conditions. Upon subsequent imaging with the set of imaging conditions, the corresponding compensation factor is called from memory and applied to the camera output. A compensation factor may be determined and stored for each hardware state and imaging condition available to the imaging system.

Abstract: A mechanical arm assembly includes an elongated housing member, having internal channels extending between its respective ends. A rod member is mounted within one of those channels, and the housing and rod member are pivotally connected at respective opposite ends to a fixed pivot post and a traveling pivot post to effect a four bar linkage arrangement. A floating spring is mounted within another internal channel separate from and approximately parallel the rod. The spring is mounted to resist the force of gravity operating upon the traveling pivot post, and is linked to that post through a fluid actuated brake cartridge slidably mounted within the channel housing the spring.

Abstract: The chair includes a movable seat and back that are configured to enhance the patient's comfort by providing lumbar support when the chair is in the recumbent position and by minimizing patient sliding within a moving chair. Chair movement is controlled by a microprocessor-based control system that includes sensing mechanisms for precisely monitoring the chair position. The sensing mechanisms are employed in conjunction with a memory device to permit the user to define a particular position into which the chair will move any time the appropriate switch is closed by the user. The chair control system diagnoses malfunctioning chair components and generates and displays data indicating the particular malfunctioning component.

Abstract: The chair includes a movable seat and back that are configured to enhance the patient's comfort by providing lumbar support when the chair is in the recumbent position and by minimizing patient sliding within a moving chair. Chair movement is controlled by a microprocessor-based control system that includes sensing mechanisms for precisely monitoring the chair position. The sensing mechanisms are employed in conjunction with a memory device to permit the user to define a particular position into which the chair will move any time the appropriate switch is closed by the user. The chair control system diagnoses malfunctioning chair components and generates and displays data indicating the particular malfunctioning component.