Abstract: This disclosure describes a wearable display system configured to project light to the eye(s) of a user to display virtual (e.g., augmented reality) image content in a vision field of the user. The system can include light source(s) that output light, spatial light modulator(s) that modulate the light to provide the virtual image content, and an eyepiece configured to convey the modulated light toward the eye(s) of the user. The eyepiece can include waveguide(s) and a plurality of in-coupling optical elements arranged on or in the waveguide(s) to in-couple the modulated light received from the spatial light modulator(s) into the waveguide(s) to be guided toward the user's eye(s). The spatial light modulator(s) may be movable, and/or may include movable components, to direct different portions of the modulated light toward different ones of the in-coupling optical elements at different times.

Abstract: The present disclosure relates to methods, cells and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interests, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have modulated lactogenic activity. The present disclosure also relates to methods and compositions for modulating pyruvate kinase muscle (PKM) expression (e.g., PKM-1 expression) in a mammalian cell to thereby reduce or eliminate the lactogenic activity of the cell, as well compositions comprising a cell having reduced or eliminated lactogenic activity and methods of using the same.

Abstract: A loop heat pipe evaporator includes a porous primary wick, and a nonporous envelope unseparatingly surrounding the primary wick. The primary wick and the envelope are of one-piece construction.

Abstract: Embodiments described herein relate to electrochemical cells that include electrodes having two-dimensional surface patterns. In some aspects, the electrochemical cell can include a cathode current collector, an anode current collector, a cathode material disposed on the cathode current collector, an anode material disposed on the anode current collector, and a separator interposed between the cathode material and the anode material. The cathode material includes a first cathode surface abutting the cathode current collector and having a first cathode surface profile that is substantially flat and planar. The cathode material further includes a second cathode surface opposite to the first cathode surface and having a second cathode surface profile comprising a plurality of projections extending in a direction away from the first cathode surface. The anode material includes a first anode surface abutting the anode current collector and having a first anode surface profile that is substantially flat and planar.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: A chain separator for separating a chain of a bicycle from a sprocket of the bicycle. The chain separator includes a body defining an outer surface and at least one projection extending from the body to define a sprocket channel. The chain is disengaged from the sprocket and positioned on the outer surface and the chain separator is positioned on the bicycle such that the sprocket is positioned within the sprocket channel.

Abstract: A device for viewing a projected image includes an input coupling grating operable to receive light related to the projected image from a light source and an expansion grating having a first grating structure characterized by a first set of grating parameters varying in one or more dimensions. The expansion grating structure is operable to receive light from the input coupling grating and to multiply the light related to the projected image. The device also includes an output coupling grating having a second grating structure characterized by a second set of grating parameters and operable to output the multiplied light in a predetermined direction.

Abstract: A coating system and related methods for an airfield surface or a roadway is described. The coating system may include a stable cationic emulsion for application to the airfield surface or the roadway. The stable cationic emulsion may include a) an asphalt blend comprising gilsonite, wherein the gilsonite is modified to possess a positive charge, b) one or more polymers, and c) one or more surfactants not including a cationic surfactant. The coating system may also include a fine aggregate material for application to the stable cationic emulsion applied to the airfield surface or the roadway.

Abstract: Methods are disclosed for determining whether a subject has a synucleinopathy. Methods are also disclosed for detecting misfolded alpha synuclein (?Syn) in a biological sample or fraction thereof. These methods include the use of an ?Syn seeding assay.

Abstract: The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.

Abstract: The present disclosure includes systems and methods for applying a coating system to a surface. An example method includes spraying an asphalt emulsion onto a surface at a rate of between about 0.12 and 0.20 gallons per square yard, the asphalt emulsion having: an asphalt blend comprising gilsonite, wherein at least a portion of the gilsonite is modified to possess a positive charge; one or more polymers, and one or more surfactants. The method may include applying a fine aggregate onto the asphalt emulsion. The fine aggregate may be applied at a rate of 2.5 pounds per square yard. In such an aspect, the asphalt emulsion may be sprayed at a rate of about 0.18 gallons per square yard, and the asphalt emulsion may contain about 56% solid asphalt residues by weight of the asphalt emulsion. In another aspect the fine aggregate may be applied at a rate of about 1.25 pounds per square yard, the asphalt emulsion may be sprayed at a rate of about 0.

Abstract: A game platform manages, on behalf of a game program, platform nodes used to execute game operations, such as physics operations, artificial intelligence operations, and player messaging operations. Via the game platform, the game program can implement relatively sophisticated and complex game operations. The game platform can implement each game operation at a corresponding platform node, wherein the platform node employs associated hardware to execute the game operation. The game platform can distribute the platform nodes at different sets of hardware resources, such as different servers, different hardware accelerators, and the like, and thereby implement more sophisticated game operations than can be implemented by the game program directly. The game platform communicates data between the game program and the platform nodes using a zero-copy transfer technique, thereby transferring data with relatively little latency.

Abstract: The present disclosure includes proppants and methods of making the proppants. The proppants herein may contain titanium dioxide, silicon dioxide, and/or aluminum dioxide. Also included in the present disclosure are methods of using the proppants to treat a reservoir.

Abstract: The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.

Abstract: A secure mechanism for adding network devices uses an unsecure guest network and a secure network both coupled to a secure hub. When an unknown device is introduced, it is initially connected to the guest network and can only communicate with the hub and with a wide area network (WAN). The unknown device is prohibited from communicating with the secure network and any device connected to the secure network. The unknown device provides credentials to the hub, which are verified with a secure database, such as a blockchain ledger, that provides manufacturer device information and certification. Upon authentication, the hub permits the identified device to connect to the secure network. The hub may also configure the now identified device for security and operational parameters. The hub may also retrieve network traffic pattern information from the secure database and use such information to monitor normal expected activity from the identified device.

Abstract: Embodiments described herein relate to electrochemical cells and production thereof under high pressure. In some aspects, a method of producing an electrochemical cell can include disposing a cathode material onto a cathode current collector to form a cathode, disposing an anode material onto an anode current collector to form an anode, and disposing the anode onto the cathode in an assembly jig with a separator positioned between the anode and the cathode to form an electrochemical cell, the assembly jig applying a force to the electrochemical cell such that a pressure in the cathode material is at least about 3,500 kPa. In some embodiments, the cathode material can be a first cathode material, and the method can further include disposing a second cathode material onto the first cathode material. In some embodiments, the first cathode material can include silicon. In some embodiments, the second cathode material can include graphite.

Abstract: The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further provided are host cell for producing said compositions, methods of making said host cells and compositions, and method of use thereof.

Abstract: A coating system and related methods for an airfield surface or a roadway is described. The coating system may include a stable cationic emulsion for application to the airfield surface or the roadway. The stable cationic emulsion may include a) an asphalt blend comprising gilsonite, wherein the gilsonite is modified to possess a positive charge, b) one or more polymers, and c) one or more surfactants not including a cationic surfactant. The coating system may also include a fine aggregate material for application to the stable cationic emulsion applied to the airfield surface or the roadway.

Abstract: The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further provided are host cell for producing said compositions, methods of making said host cells and compositions, and method of use thereof.

Abstract: The present disclosure includes proppants and methods of making the proppants. The proppants herein may contain titanium dioxide, silicon dioxide, and/or aluminum dioxide. Also included in the present disclosure are methods of using the proppants to treat a reservoir.