Patents by Inventor Bradley Richard Snedecor

Bradley Richard Snedecor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of making fucosylated and afucosylated forms of a protein
    Patent number: 11802165
    Abstract: The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: October 31, 2023
    Assignee: Genentech, Inc.
    Inventors: Shahram Misaghi, John B. Lowe, Bradley Richard Snedecor
  • EXPRESSION OF FC-CONTAINING PROTEINS
    Publication number: 20230159625
    Abstract: The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further provided are host cell for producing said compositions, methods of making said host cells and compositions, and method of use thereof.
    Type: Application
    Filed: January 18, 2023
    Publication date: May 25, 2023
    Inventors: Benjamin HALEY, Zhilan HU, John C. JOLY, Amy Y. SHEN, Bradley Richard SNEDECOR
  • Expression of Fc-containing proteins
    Patent number: 11591382
    Abstract: The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further provided are host cell for producing said compositions, methods of making said host cells and compositions, and method of use thereof.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: February 28, 2023
    Assignee: Genentech, Inc.
    Inventors: Benjamin Haley, Zhilan Hu, John C. Joly, Amy Y. Shen, Bradley Richard Snedecor
  • METHODS OF PROTEIN PRODUCTION
    Publication number: 20210230658
    Abstract: A method of reducing glycation of an amino acid in a protein produced by a host cell in cell culture medium is disclosed.
    Type: Application
    Filed: April 2, 2021
    Publication date: July 29, 2021
    Applicant: GENENTECH, INC.
    Inventors: Inn Huam Yuk, Bradley Richard Snedecor, Dana Christian Andersen
  • METHODS OF MAKING FUCOSYLATED AND AFUCOSYLATED FORMS OF A PROTEIN
    Publication number: 20210214462
    Abstract: The present application relates to methods of producing a protein in fucosydated and afucosylated forms at a predetermined ratio.
    Type: Application
    Filed: January 13, 2021
    Publication date: July 15, 2021
    Applicant: Genentech, Inc.
    Inventors: Shahram MISAGHI, John B. LOWE, Bradley Richard SNEDECOR
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 11046987
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: June 29, 2021
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • Methods of protein production
    Patent number: 10982250
    Abstract: A method of reducing glycation of an amino acid in a protein produced by a host cell in cell culture medium is disclosed.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 20, 2021
    Assignee: Genentech, Inc.
    Inventors: Inn Huam Yuk, Bradley Richard Snedecor, Dana Christian Andersen
  • Methods of making fucosylated and afucosylated forms of a protein
    Patent number: 10975168
    Abstract: The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: April 13, 2021
    Assignee: GENENTECH, INC.
    Inventors: Shahram Misaghi, John B. Lowe, Bradley Richard Snedecor
  • MODULATING LACTOGENIC ACTIVITY IN MAMMALIAN CELLS
    Publication number: 20210009988
    Abstract: The present disclosure relates to methods, cells and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interests, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have modulated lactogenic activity. The present disclosure also relates to methods and compositions for modulating pyruvate kinase muscle (PKM) expression (e.g., PKM-1 expression) in a mammalian cell to thereby reduce or eliminate the lactogenic activity of the cell, as well compositions comprising a cell having reduced or eliminated lactogenic activity and methods of using the same.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 14, 2021
    Applicant: GENENTECH, INC.
    Inventors: Shahram Misaghi, Masaru Ken Shiratori, Bradley Richard Snedecor, Michael W. Laird
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20200377919
    Abstract: The present invention provides ethods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Applicant: Genentech, Inc.
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • Decreasing lactate level and increasing polypeptide production by down regulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 10704071
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 7, 2020
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20190040435
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: May 31, 2018
    Publication date: February 7, 2019
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • EXPRESSION OF FC-CONTAINING PROTEINS
    Publication number: 20180282398
    Abstract: The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further provided are host cell for producing said compositions, methods of making said host cells and compositions, and method of use thereof.
    Type: Application
    Filed: September 21, 2016
    Publication date: October 4, 2018
    Inventors: Benjamin HALEY, Zhilan HU, John C. JOLY, Amy Y. SHEN, Bradley Richard SNEDECOR
  • METHODS OF MAKING FUCOSYLATED AND AFUCOSYLATED FORMS OF A PROTEIN
    Publication number: 20180251572
    Abstract: The present application relates to methods of producing a protein in fucosylated and afucosylated forms at a predetermined ratio.
    Type: Application
    Filed: May 1, 2018
    Publication date: September 6, 2018
    Inventors: Shahram MISAGHI, John B. LOWE, Bradley Richard SNEDECOR
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 10011856
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20170191102
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: September 16, 2016
    Publication date: July 6, 2017
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 9487809
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: November 8, 2016
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • METHODS OF PROTEIN PURIFICATION
    Publication number: 20100256336
    Abstract: A method of reducing glycation of an amino acid in a protein produced by a host cell in cell culture medium is disclosed.
    Type: Application
    Filed: September 17, 2007
    Publication date: October 7, 2010
    Inventors: Inn Huam Yuk, Bradley Richard Snedecor, Dana Christian Andersen