Patents by Inventor Bradley T. Estes

Bradley T. Estes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180289490
    Abstract: A method has been developed for repairing a cartilage lesion. The method includes bringing a three-dimensional porous substrate into direct contact with prepared bone. The three-dimensional porous substrate is fixedly coupled to a three-dimensional scaffold such that the substrate supports the scaffold. The three-dimensional porous substrate comprises at least three layers of woven fibers. The substrate is configured to be inserted into bone tissue including cartilage lesions such that the substrate and the scaffold replace the bone tissue including the cartilage lesions. The substrate and scaffold are further configured such that after the substrate and the scaffold have replaced the bone tissue including the cartilage lesions, the substrate and scaffold promote growth and integration of new bone tissue into the implant.
    Type: Application
    Filed: June 15, 2018
    Publication date: October 11, 2018
    Inventors: Bradley T. Estes, Farshid Guilak, Franklin Thomas Moutos
  • Patent number: 10022231
    Abstract: An implant is configured for repair and regeneration of cartilage lesions. The implant includes a three-dimensional woven textile scaffold and a three-dimensional rigid, porous substrate. The scaffold is bonded to the substrate such that the substrate supports the scaffold. The substrate is configured to be inserted into bone tissue including cartilage lesions such that the substrate and the scaffold replace the bone tissue including the cartilage lesions. The substrate and scaffold are further configured such that after the substrate and the scaffold have replaced the bone tissue including the cartilage lesions, the substrate and scaffold promote growth and integration of new bone tissue into the implant.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 17, 2018
    Assignee: Cytex Therapeutics, Inc.
    Inventors: Bradley T. Estes, Farshid Guilak, Franklin Thomas Moutos
  • Publication number: 20180021138
    Abstract: An implant is configured for repair and regeneration of cartilage lesions. The implant includes a three-dimensional woven textile scaffold and a three-dimensional rigid, porous substrate. The scaffold is bonded to the substrate such that the substrate supports the scaffold. The substrate is configured to be inserted into bone tissue including cartilage lesions such that the substrate and the scaffold replace the bone tissue including the cartilage lesions. The substrate and scaffold are further configured such that after the substrate and the scaffold have replaced the bone tissue including the cartilage lesions, the substrate and scaffold promote growth and integration of new bone tissue into the implant.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 25, 2018
    Inventors: Bradley T. Estes, Farshid Guilak, Franklin Thomas Moutos
  • Publication number: 20170312392
    Abstract: A composition for use in the treatment of osteoarthritis in a subject includes an adipose-derived stem cell and an effective amount of a biologically active agent. The composition also includes a pharmaceutically acceptable carrier or excipient. The biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof. The treatment includes exposing the ADS cell to an effective amount of said biologically active agent. The effective amount of the biologically active agent is sufficient to induce the adipose-derived stem cell to differentiate into a cell capable of treating the osteoarthritis in the subject upon administration of the composition to the subject.
    Type: Application
    Filed: May 16, 2017
    Publication date: November 2, 2017
    Inventors: Farshid Guilak, Bradley T. Estes, Franklin Thomas Moutos
  • Publication number: 20170165400
    Abstract: A method is used for preparing a product for use in repairing a lesion or defect at a tissue site in a human or animal patient body. The method includes obtaining tissue from a donor human or animal body and freezing the obtained tissue. The method further includes pulverizing the frozen tissue and suspending the pulverized tissue in a fluid. The method further includes homogenizing the tissue suspension and precipitating tissue particles from the homogenized tissue suspension. The method further includes re-suspending the precipitated tissue particles and lyophilizing the tissue re-suspension to provide the product to be used in repairing the lesion or defect.
    Type: Application
    Filed: February 28, 2017
    Publication date: June 15, 2017
    Inventors: Hani Awad, Bradley T. Estes, Farshid Guilak
  • Patent number: 9649409
    Abstract: Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 16, 2017
    Assignee: Cytex Therapeutics, Inc.
    Inventors: Farshid Guilak, Bradley T. Estes, Franklin Thomas Moutos
  • Publication number: 20160081807
    Abstract: A scaffold is provided which facilitates integration of both bone and cartilage at an osteochondral lesion, thereby acting as a tissue engineered interface or tissue engineered junction between the two different tissues. The method and systems for engineering this interface may be acellular or may be loaded with cells prior to use.
    Type: Application
    Filed: September 23, 2015
    Publication date: March 24, 2016
    Inventors: Bradley T. Estes, Franklin Thomas Moutos, Farshid Guilak
  • Patent number: 8911480
    Abstract: This invention relates to orthopedic implants and to methods of treating bone defects. More specifically, but not exclusively, the present invention is directed to non-metallic implants and to methods for intra-operative assembly and fixation of orthopedic implants to facilitate medical treatment. The non-metallic implant assembly can be secured to underlying tissue by a fastener, such as a bone screw, that is capable of swelling on contact with fluid in the underlying tissue. Alternatively, the non-metallic implant assembly can be assembled intra-operatively using a fastener that is adhesively bonded to a bone plate or the bone plate can be deformed using heat, force, or solvents to inhibit withdrawal of the fastener. In preferred embodiments, both the fastener and the bone plate are formed of biodegradable material.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: December 16, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Hai H. Trieu, Jeff R. Justis, Troy D. Drewry, Michael C. Sherman, Bradley J. Coates, Bradley T. Estes
  • Publication number: 20140227336
    Abstract: Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 14, 2014
    Applicant: Cytex Therapeutics, Inc.
    Inventors: Farshid Guilak, Bradley T. Estes, Franklin Thomas Moutos
  • Patent number: 8691542
    Abstract: The presently disclosed subject matter generally relates to methods and systems for facilitating the growth and differentiation of adipose-derived stem cells for laboratory and therapeutic applications. The cells can be employed alone or in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: April 8, 2014
    Assignee: Cytex Therapeutics, Inc.
    Inventors: Farshid Guilak, Bradley T. Estes, Franklin Thomas Moutos
  • Patent number: 8617224
    Abstract: A plate of biocompatible material is provided having curvature in two planes such that it conforms to the curvature of the L5 vertebral body and to the patient's lordotic curve. Holes are provided receiving screws for anchorage in the vertebral body and sacrum. A flange or foot portion on the plate provides a wider base end area for support in the L5-S1 interspace. The foot portion is also arranged for appropriate entry angle of screws into the sacrum such as to improve anchorage in the sacrum. Anti-backout and low profile features are incorporated. The anterior lumbar plate is situated to maintain the anterior interbody bone graft in compression by resisting tensile forces during extension.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: December 31, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jeffrey Kozak, Bradley T. Estes, Lawrence M. Boyd
  • Publication number: 20130030535
    Abstract: This invention relates to methods and instruments for performing a surgical procedure in a disc space between adjacent vertebrae. A cannula is inserted to create a working channel through the skin and tissue of a patient using a transforaminal approach to the disc space. A viewing element is used to visualize working end of the cannula and the disc space. A facetectomy is performed through the working channel to access the disc space. The disc space is prepared with various instruments, such as distractors, shims, chisels and distractor-cutters that extend through the working channel. At least implant is inserted into the disc space. The procedure allows bi-lateral support of the adjacent vertebrae with the at least one implant inserted via a unitary, minimally invasive approach to disc space.
    Type: Application
    Filed: October 2, 2012
    Publication date: January 31, 2013
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Kevin T. Foley, John L. White, Bradley T. Estes, Mingyan Liu, Loic Josse, Jeffrey D. Moore
  • Patent number: 8308803
    Abstract: This invention relates to methods and instruments for performing a surgical procedure in a disc space between adjacent vertebrae. A cannula is inserted to create a working channel through the skin and tissue of a patient using a transformational approach to the disc space. A viewing element is used to visualize working end of the cannula and the disc space. A facetectomy is performed through the working channel to access the disc space. The disc space is prepared with various instruments, such as distractors, shims, chisels and distractor-cutters that extend through the working channel. At least implant is inserted into the disc space. The procedure allows bi-lateral support of the adjacent vertebrae with the at least one implant inserted via a unitary, minimally invasive approach to disc space.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: November 13, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Kevin T. Foley, John L. White, Bradley T. Estes, Mingyan Liu, Loic Josse, Jeffrey D. Moore
  • Patent number: 8177845
    Abstract: An osteogenic material packing device is used to pack osteogenic material onto a spinal fusion device. The packing device has a cavity defined therein, which is adapted to receive the spinal fusion device. The packing device further includes an access port, which intersects the cavity to receive the osteogenic material. A cannula is coupled to the packing device and an inserter is coupled to the fusion device in order to insert the fusion device into the packing device. Osteogenic material is packed through the access port around the fusion device. The fusion device then is slid through the cannula and inserted in the intervertebral space between adjacent vertebrae.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: May 15, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Bradley T. Estes
  • Patent number: 8142438
    Abstract: This invention relates to methods and instruments for performing a surgical procedure in a disc space between adjacent vertebrae. The instruments include a distractor and a cutting instrument. In one embodiment the distractor includes a body portion and a pair of flanges extending along opposite sides of the body portion such that a slot is formed between the flanges and the body portion. The cutting instrument is positionable over the body portion and into the slots of the distractor so that the flanges are positioned between the cutting instrument and the adjacent tissue.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: March 27, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Kevin T. Foley, Jeffrey D. Moore, Bradley T. Estes, Mingyan Liu, Loic Josse
  • Patent number: 8105339
    Abstract: A guide is disclosed for use in performing spinal surgery to prepare across a spinal disc and adjacent vertebrae an implantation space. The guide is associated with a computer controlled surgical navigation system employing an energy-detecting array to track positions of the guide in three dimensional space relative to a known reference point. The guide includes a body for providing protected access to prepare across the spinal disc and into the adjacent vertebrae the implantation space. The body has a passage adapted to receive a bone removal device for forming the implantation space through the body. At least one electrically energizable energy emitter array is attached to the body for use in identifying the location of the guide relative to the adjacent vertebrae. A system and method for using the guide in spinal surgery are also disclosed.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: January 31, 2012
    Assignee: Sofamor Danek Holdings, Inc.
    Inventors: Anthony J. Melkent, Kevin T. Foley, Bradley T. Estes, Joseph Chaudoin
  • Patent number: 8066710
    Abstract: A method and instrumentation for spinal interbody fusion is disclosed. The instruments and methods are particularly adapted for interbody fusion from a posterior approach to the spine. One instrument is a retractor having a lockable pivotally mounted handle. Another instrument is a template for straddling the dura. A modular distractor is also provided and preferably includes a tapered shaft with a visualization window disposed therein. Yet another instrument is a depth gauge to verify bone opening depth and dimension, preferably including a radiopaque portion. A method contemplates the use of these instruments to prepare a disc space to receive an implant.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: November 29, 2011
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Bradley T. Estes, Regis W. Haid, Jr., Eddie F. Ray, III, Jeffrey D. Moore, Gerald E. Rodts, Jr.
  • Publication number: 20110288587
    Abstract: A plate of biocompatible material is provided having curvature in two planes such that it conforms to the curvature of the L5 vertebral body and to the patient's lordotic curve. Holes are provided receiving screws for anchorage in the vertebral body and sacrum. A flange or foot portion on the plate provides a wider base end area for support in the L5-S1 interspace. The foot portion is also arranged for appropriate entry angle of screws into the sacrum such as to improve anchorage in the sacrum. Anti-backout and low profile features are incorporated. The anterior lumbar plate is situated to maintain the anterior interbody bone graft in compression by resisting tensile forces during extension.
    Type: Application
    Filed: August 5, 2011
    Publication date: November 24, 2011
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Jeffrey Kozak, Bradley T. Estes, Lawrence M. Boyd
  • Patent number: 8038714
    Abstract: Intervertebral spacers and methods of promoting fusion bone growth in the space between adjacent vertebrae are provided. The spacers include an elongated body having a first end, a second end and an outer surface. Side walls connect the first and second ends. The elongated body also defines an interior cavity. The side wall defines an opening to the interior cavity in a side of the elongated body. At least one of the first and second ends has a discontinuity, such as a concave surface, for nesting with an adjacent spacer. The methods of promoting fusion bone growth include utilizing the inventive spacers described herein.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: October 18, 2011
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence M. Boyd, J. Kenneth Burkus, John D. Dorchak, Bradley T. Estes, Eddie F. Ray, III
  • Patent number: 8016863
    Abstract: A plate of biocompatible material is provided having curvature in two planes such that it conforms to the curvature of the L5 vertebral body and to the patient's lordotic curve. Holes are provided receiving screws for anchorage in the vertebral body and sacrum. A flange or foot portion on the plate provides a wider base end area for support in the L5-S1 interspace. The foot portion is also arranged for appropriate entry angle of screws into the sacrum such as to improve anchorage in the sacrum. Anti-backout and low profile features are incorporated. The anterior lumbar plate is situated to maintain the anterior interbody bone graft in compression by resisting tensile forces during extension.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: September 13, 2011
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jeffrey Kozak, Bradley T. Estes, Lawrence M. Boyd