Patents by Inventor Bradley T. Lang

Bradley T. Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20230346947
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: November 15, 2022
    Publication date: November 2, 2023
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 11497812
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: November 15, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • CRYSTALLINE FORMS OF MULTICYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20220024851
    Abstract: The invention is directed at esylate and salicylate salts of cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine and their pharmaceutical composition. The invention is also directed at the use esylate and salicylate salts of cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-yclohexylphenyl)prop-2-enylamine and their pharmaceutical composition in treatment of myelin-related disorders.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 27, 2022
    Inventors: Bradley T. Lang, Emily M. Rigsbee, Ekaterina V. Albert
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20210205460
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: August 3, 2020
    Publication date: July 8, 2021
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods of treating root avulsion injury
    Patent number: 10898550
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 26, 2021
    Assignees: CASE WESTERN RESERVE UNIVERSITY, VERSITECH LIMITED
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY
    Publication number: 20210008148
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 14, 2021
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods for treating heart disease and/or injury
    Patent number: 10786541
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: September 29, 2020
    Assignees: CASE WESTERN RESERVE UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 10729777
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: August 4, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • COMPOSITIONS AND METHODS OF TREATING ROOT AVULSION INJURY
    Publication number: 20200000888
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: April 11, 2019
    Publication date: January 2, 2020
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY
    Publication number: 20190290717
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: February 19, 2019
    Publication date: September 26, 2019
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods of treating root avulsion injury
    Patent number: 10258672
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: April 16, 2019
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNIVERSITY OF HONG KONG
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • Compositions and methods for treating heart disease and/or injury
    Patent number: 10206967
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: February 19, 2019
    Assignees: CASE WESTERN RESERVE UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20180228905
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 16, 2018
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 9937242
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: April 10, 2018
    Assignee: Case Western Reserve University
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-lan Weng
  • COMPOSITIONS AND METHODS OF TREATING ROOT AVULSION INJURY
    Publication number: 20170072026
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 16, 2017
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng
  • COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY
    Publication number: 20170035830
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: September 6, 2016
    Publication date: February 9, 2017
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • COMPOSITIONS AND METHODS FOR INIHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20150366949
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: April 9, 2013
    Publication date: December 24, 2015
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-lan Weng