Patents by Inventor Bradley William Caprathe

Bradley William Caprathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C4-MODIFIED OLEANOLIC ACID DERIVATIVES FOR INHIBITION OF IL-17 AND OTHER USES
    Publication number: 20230250130
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Application
    Filed: January 4, 2023
    Publication date: August 10, 2023
    Inventors: Melean VISNICK, Xin JIANG, Martha R. HOTEMA, Chitase LEE, Bradley William CAPRATHE, William H. ROARK, Gary L. BOLTON
  • C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses
    Patent number: 11584775
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: February 21, 2023
    Assignee: REATA PHARMACEUTICALS, Inc.
    Inventors: Melean Visnick, Xin Jiang, Martha R. Hotema, Chitase Lee, Bradley William Caprathe, William H. Roark, Gary L. Bolton
  • PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF ROR-GAMMA AND OTHER USES
    Publication number: 20220135534
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 5, 2022
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Christopher F. BENDER, Melean VISNICK, Martha R. HOTEMA, Zachary S. SHELDON, Chitase LEE, Bradley William CAPRATHE, Gary BOLTON, Brian KORNBERG
  • Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
    Patent number: 11292781
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Grant
    Filed: December 16, 2017
    Date of Patent: April 5, 2022
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Xin Jiang, Christopher F. Bender, Melean Visnick, Martha R. Hotema, Zachary S. Sheldon, Chitase Lee, Bradley William Caprathe, Gary Bolton, Brian Kornberg
  • Imidazolyl tricyclic enones as antioxidant inflammation modulators
    Patent number: 11059792
    Abstract: Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: July 13, 2021
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Xin Jiang, Bradley William Caprathe, Chitase Lee, Gary Bolton, Christopher F. Bender, Melean Visnick
  • PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF ROR-GAMMA AND OTHER USES
    Publication number: 20200131148
    Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR? and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
    Type: Application
    Filed: December 16, 2017
    Publication date: April 30, 2020
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Christopher F. BENDER, Melean VISNICK, Martha R. HOTEMA, Zachary S. SHELDON, Chitase LEE, Bradley William CAPRATHE, Gary BOLTON, Brian KORNBERG
  • C4-MODIFIED OLEANOLIC ACID DERIVATIVES FOR INHIBITION OF IL-17 AND OTHER USES
    Publication number: 20190153022
    Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.
    Type: Application
    Filed: September 23, 2016
    Publication date: May 23, 2019
    Inventors: Melean VISNICK, Xin JIANG, Martha R. HOTEMA, Chitase LEE, Bradley William CAPRATHE, William H. ROARK, Gary L. BOLTON
  • IMIDAZOLYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS
    Publication number: 20180127380
    Abstract: Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
    Type: Application
    Filed: February 12, 2016
    Publication date: May 10, 2018
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Bradley William CAPRATHE, Chitase LEE, Gary BOLTON, Christopher F. BENDER, Melean VISNICK
  • Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
    Patent number: 9464082
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: October 11, 2016
    Assignees: AbbVie Inc., Reata Pharmaceuticals, Inc.
    Inventors: Pamela Donner, Rolf Wagner, Jason Shanley, Howard Heyman, Allan Krueger, Hui-Ju Chen, Michael Rozema, David Grampovnik, Melean Visnick, Eric Anderson, Xin Jiang, Christopher F. Bender, Gary Louis Bolton, Bradley William Caprathe, Chitase Lee, William Howard Roark
  • ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS
    Publication number: 20150225397
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
    Type: Application
    Filed: January 23, 2015
    Publication date: August 13, 2015
    Inventors: Pamela Donner, Rolf Wagner, Jason Shanley, Howard Heyman, Allan Krueger, Hui-Ju Chen, Michael Rozema, David Grampovnik, Melean Visnick, Eric Anderson, Xin Jiang, Christopher F. Bender, Gary Louis Bolton, Bradley William Caprathe, Chitase Lee, William Howard Roark
  • Hydroxamate inhibitors of interleukin-1.beta. converting enzyme
    Patent number: 5919790
    Abstract: The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 6, 1999
    Assignees: Warner-Lambert Company, BASF Aktiengesellsschaft
    Inventors: Hamish John Allen, Kenneth Dale Brady, Bradley William Caprathe, Paul Galatsis, John Lodge Gilmore, Sheryl Jeanne Hays, Robert Vincent Talanian, Nigel Walker, Joseph Scott Warmus
  • 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
    Patent number: 5652237
    Abstract: This invention concerns certain 2-substituted-3,1-benzoxazin-4-ones and benzthiazinones as complement Clr protease inhibitors and antiinflammatory agents, pharmaceutical compositions containing them, methods of using them, and processes for their preparation.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: July 29, 1997
    Assignee: Warner-Lambert Company
    Inventors: Corinne Elizabeth Augelli-Szafran, Bradley William Caprathe, John Lodge Gilmore, Sheryl Jeanne Hays, Juan Carlos Jaen, Jan Ruth Penvose-Yi