Patents by Inventor Brahim HEDDI

Brahim HEDDI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • G-quadruplex-containing antisense oligonucleotides
    Patent number: 11390867
    Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: July 19, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Anh Tuan Phan, Kah Wai Lim, Vee Vee Cheong, Christopher Brian Henry Jacques Lech, Brahim Heddi
  • G-QUADRUPLEX-CONTAINING ANTISENSE OLIGONUCLEOTIDES
    Publication number: 20210139893
    Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 13, 2021
    Inventors: Anh Tuan PHAN, Kah Wai LIM, Vee Vee CHEONG, Christopher Brian Henry Jacques LECH, Brahim HEDDI
  • Peptides binding to parallel-stranded G-quadruplexes
    Patent number: 9815868
    Abstract: A peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof is provided. Also provided are conjugates of such a peptide, the use of the peptide or the conjugates as a medicament, and methods for the detection of parallel-stranded G-quadruplexes.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: November 14, 2017
    Assignee: Nanyang Technological University
    Inventors: Anh Tuan Phan, Brahim Heddi, Vee Vee Cheong, Herry Martadinata
  • PEPTIDES BINDING TO PARALLEL-STRANDED G-QUADRUPLEXES
    Publication number: 20160115201
    Abstract: This invention relates to a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof. The present invention also relates to conjugates of said peptide, the use of the peptide or the conjugate as a medicament and to methods for the detection of parallel-stranded G-quadruplexes.
    Type: Application
    Filed: May 20, 2014
    Publication date: April 28, 2016
    Inventors: Anh Tuan PHAN, Brahim HEDDI, Vee Vee CHEONG, Herry MARTADINATA