Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

Abstract: A system for monitoring of vehicles and particularly heavy vehicles and their compliance with specific network (e.g. road) access conditions uses vehicle telematics solutions. The system includes an in-vehicle unit (IVU) associated with a vehicle being monitored. The IVU includes a receiver for receiving positioning signals, a processor for processing a time-marked log of vehicle data, a storage element for storing the time-marked log and a first wireless communication element for communicating time marked data to a Service Provider (SP) processing apparatus. One or more Service Providers operate Service Provider (SP) processing apparatus. The SP processing apparatus include a SP wireless communication element for receiving time-marked data from one or more IVUs and a SP processor for processing received data.

Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

Abstract: An automotive glazing (10) comprising a single ply of annealed or semi-toughened glass (12) having a film of plastic material (16) bonded to a major surface of the glass ply by a contact adhesive (14).