Patents by Inventor Bram Harmsen

Bram Harmsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FASORACETAM CRYSTALLINE FORMS
    Publication number: 20250129043
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Application
    Filed: August 30, 2024
    Publication date: April 24, 2025
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Bram Harmsen
  • Fasoracetam crystalline forms
    Patent number: 12110284
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: October 8, 2024
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Tom Leyssens, Bram Harmsen
  • SOLID FORMS OF FASORACETAM
    Publication number: 20230203001
    Abstract: The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
    Type: Application
    Filed: February 16, 2023
    Publication date: June 29, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Richard Alan Couch, Michael Paul Rene Guillot, Bram Harmsen, Thomas R. Bailey, Martin Appelmans
  • Process for Producing an Aroma-Laden Gas, Aroma-Laden Gas, and Use of the Aroma-Laden Gas
    Publication number: 20230112273
    Abstract: A process for producing an aroma-laden gas (10) comprises the following steps: a) providing a liquid phase (5), which contains a solvent and one or several aromatic substances (1, 2, 3); b) guiding through a solid phase extraction column (3) of the liquid phase provided in step (a) by obtaining the solid phase (35) laden with one or several aromatic substances; separating one or several aromatic substances from the laden solid phase by means of at least one gas (2) in a liquid and/or supercritical state; and optionally d) collecting the gas (10), which is laden with one or several aromatic substances (1, 2, 3).
    Type: Application
    Filed: March 12, 2021
    Publication date: April 13, 2023
    Applicant: Döhler GmbH
    Inventors: Bram HARMSEN, Harald ROSENBLATT, Klaus GÜNTHER
  • FASORACETAM CRYSTALLINE FORMS
    Publication number: 20230088814
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Application
    Filed: November 30, 2022
    Publication date: March 23, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Tom Leyssens, Bram Harmsen
  • Solid forms of fasoracetam
    Patent number: 11608324
    Abstract: The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: March 21, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Richard Alan Couch, Michael Paul Rene Guillot, Bram Harmsen, Thomas R. Bailey, Martin Appelmans
  • Fasoracetam crystalline forms
    Patent number: 11535604
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: December 27, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Tom Leyssens, Bram Harmsen
  • Solid Forms of Fasoracetam
    Publication number: 20210355102
    Abstract: The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
    Type: Application
    Filed: January 17, 2019
    Publication date: November 18, 2021
    Inventors: Tom Leyssens, Richard Alan Couch, Michael Paul Rene Guillot, Bram Harmsen, Thomas R. Bailey, Martin Appelmans
  • Fasoracetam Crystalline Forms
    Publication number: 20210047288
    Abstract: The disclosure is directed to crystalline forms and mixtures thereof of R-fasoracetam. Such crystalline forms include Form II monohydrate R-fasoracetam and the anhydrate form of R-fasoracetam. The disclosure further includes mixtures of the anhydrate form of R-fasoracetam together with one or more of Form I monohydrate R-fasoracetam and Form II monohydrate R-fasoracetam.
    Type: Application
    Filed: January 17, 2019
    Publication date: February 18, 2021
    Inventors: Tom Leyssens, Bram Harmsen