Patents by Inventor Branden Moriarity

Branden Moriarity has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tumor infiltrating lymphocytes and methods of therapy
    Patent number: 11154574
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: October 26, 2021
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Modified cells and methods of therapy
    Patent number: 11147837
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 19, 2021
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20210277366
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 9, 2021
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems and methods
    Patent number: 11111483
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 7, 2021
    Assignee: B-MoGen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • MODIFIED CELLS AND METHODS OF THERAPY
    Publication number: 20210260117
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: August 26, 2020
    Publication date: August 26, 2021
    Inventors: Branden MORIARITY, Beau WEBBER, Modassir CHOUDHRY, R. Scott MCIVOR, David LARGAESPADA, Steven A. ROSENBERG, Douglas C. PALMER, Nicholas P. RESTIFO
  • LYMPHOHEMATOPOIETIC ENGINEERING USING CAS9 BASE EDITORS
    Publication number: 20210040507
    Abstract: Provided herein are methods and systems for targeted gene disruption (knock-out, missense mutation) and targeted gene knock-in in mammalian cells using base editors and guide RNAs (gRNAs) designed to target splice acceptor-splice donor sites. Also provided herein are universally acceptable genetically engineered cells comprising targeted disruptions in immunotherapy-related genes and comprising a CAR/TCR for therapeutic applications.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 11, 2021
    Inventors: Branden Moriarity, Beau Webber, Cara-Lin Lonetree, Miechaleen Diers, Mitchell Kluesner, Walker Lahr, Emily Joy Pomeroy
  • Tumor infiltrating lymphocytes and methods of therapy
    Patent number: 10912797
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 9, 2021
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20200353001
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: June 12, 2020
    Publication date: November 12, 2020
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Enhanced hAT Family Transposon-Mediated Gene Transfer and Associated Compositions, Systems, and Methods
    Publication number: 20200339965
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: February 12, 2020
    Publication date: October 29, 2020
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
    Publication number: 20200330517
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Application
    Filed: June 2, 2020
    Publication date: October 22, 2020
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20200323902
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 15, 2020
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20200306309
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20200306310
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
    Publication number: 20200289570
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
    Publication number: 20200289571
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • VIRAL METHODS OF MAKING GENETICALLY MODIFIED CELLS
    Publication number: 20190382799
    Abstract: The present disclosure provides methods of producing a population of genetically modified cells using viral or non-viral vectors. Also disclosed are modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.
    Type: Application
    Filed: April 19, 2019
    Publication date: December 19, 2019
    Inventors: Thomas HENLEY, Eric RHODES, Modassir CHOUDHRY, Branden MORIARITY, Beau WEBBER
  • VIRAL METHODS OF T CELL THERAPY
    Publication number: 20190374576
    Abstract: Methods of producing a population of genetically modified cells using viral or non-viral vectors. Disclosed are also modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.
    Type: Application
    Filed: April 19, 2019
    Publication date: December 12, 2019
    Inventors: Thomas HENLEY, Eric RHODES, Modassir CHOUDHRY, Branden MORIARITY, Beau WEBBER, Steven A. ROSENBERG, Douglas C. PALMER, Nicholas P. RESTIFO
  • Modified cells and methods of therapy
    Patent number: 10406177
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: September 10, 2019
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 10227574
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: March 12, 2019
    Assignee: B-Mogen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20190060363
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: November 6, 2018
    Publication date: February 28, 2019
    Inventors: Branden MORIARITY, Beau WEBBER, Modassir CHOUDHRY, Steven A. ROSENBERG, Douglas C. PALMER, Nicholas P. RESTIFO