Patents by Inventor Branden S. Moriarity

Branden S. Moriarity has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCING EFFICIENCY OF TARGETED GENE KNOCKIN BY BASE EDITORS
    Publication number: 20240101993
    Abstract: The present invention provides genomic engineering methods that utilize base editors to perform targeted gene knockins and gene knockouts with high efficiency. Cells that have been genetically modified according to these methods are also provided, as are methods of using the modified cells in a treatment for cancer.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 28, 2024
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Beau R. Webber, Branden S. Moriarity, Walker Lahr, Nicholas Slipek, Mitchell G. Kluesner
  • GENOME EDITED PRIMARY B CELL AND METHODS OF MAKING AND USING
    Publication number: 20220168342
    Abstract: Genonie-edited primary B cells, methods of making genome-edited primary B cells, a therapeutic cassette that can be introduced into primary B cells, and methods of using the genome-edited primary B cells and the therapeutic cassette.
    Type: Application
    Filed: September 12, 2017
    Publication date: June 2, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Branden S. MORIARITY, John HUNZEKER, Matthew JOHNSON, Kanut LAOHARAWEE
  • GENOME ENGINEERING PRIMARY MONOCYTES
    Publication number: 20210254068
    Abstract: The present disclosure relates generally to methods and tools for engineering a genome of a mammalian monocyte. In particular, the present disclosure relates to mammalian monocytes having at least one altered locus, and reagents for production thereof.
    Type: Application
    Filed: June 19, 2019
    Publication date: August 19, 2021
    Applicant: Regents of the University of Minnesota
    Inventors: Branden S. MORIARITY, Kanut LAOHARAWEE, Matthew J. JOHNSON
  • GENOME-EDITED NK CELL AND METHODS OF MAKING AND USING
    Publication number: 20200208111
    Abstract: Described here are a genome-edited primary NK cell, methods that includes editing a genome of a primary natural killer (NK) cell, and methods of administering a genome-edited primary NK cell. The primary NK cell may be rested or stimulated.
    Type: Application
    Filed: June 9, 2017
    Publication date: July 2, 2020
    Inventors: Branden S. Moriarity, John Hunzeker, Emily Pomeroy
  • VECTORS AND SYSTEM FOR MODULATING GENE EXPRESSION
    Publication number: 20190038780
    Abstract: A polynucleotide that modulates transcription from a plurality of genomic targets can include, generally, a polynucleotide encoding a gRNA array and a polynucleotide sequence encoding a nuclease-deficient Cas9 polypeptide. The polynucleotide encoding a gRNA array generally includes polynucleotides encoding at least two gRNAs operably linked to an inducible regulatory sequence.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 7, 2019
    Inventors: David A. Largaespada, Branden S. Moriarity
  • CONDITIONAL RESCUE SYSTEM, CELLS, AND METHODS
    Publication number: 20170298391
    Abstract: A conditional rescue system generally includes a gene transfer system, a polynucleotide including a nuclease-resistant target coding region, and a coding region encoding a conditionally-lethal polypeptide. The gene transfer system is effective to integrate into host cell DNA. The polynucleotide including the nuclease-resistant target coding region is under transcriptional control of an inducible promoter. The coding region encoding a conditionally-lethal polypeptide is transcriptionally linked to the target coding region.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 19, 2017
    Inventors: David A. Largaespada, Branden S. Moriarity, Robert A. Klink