Patents by Inventor Brandi D. Sanders

Brandi D. Sanders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying a compound that modulates SIR2 protein activity
    Patent number: 8180580
    Abstract: The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: May 15, 2012
    Assignee: The Wistar Institute
    Inventors: Ronen Marmorstein, Brandi D. Sanders
  • Compounds and methods for modulating sir2 protein activity
    Publication number: 20090326007
    Abstract: The present invention embraces compounds that modulate the activity of sirtuin deacetylase protein family members and use thereof for modulating Sir2 activity as well as for preventing or treating diseases or disorders associated with Sir2.
    Type: Application
    Filed: July 29, 2009
    Publication date: December 31, 2009
    Inventors: Ronen Marmorstein, Brandi D. Sanders
  • Method for identifying a compound that modulates SIR2 protein activity
    Publication number: 20080305496
    Abstract: The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided.
    Type: Application
    Filed: January 31, 2008
    Publication date: December 11, 2008
    Inventors: Ronen Marmorstein, Brandi D. Sanders