Abstract: The present invention is related to the generation and use of secreted fusogenic vesicles incorporating engineered viral glycoprotein, or engineered endogenous human fusiogenic proteins derived from human endogenous retroviruses proteins, such vesicles being generally referred to as “gectosomes.” The present invention is further related to the use of engineered gectosomes to deliver therapeutic molecules or antigens to cell and tissues in a targeted manner, as well as systems and methods for using gectosomes to screen for therapeutically relevant compounds or therapeutic antibodies.

Abstract: Disclosed are a combination controller unit and a carrier device for handheld electronic devices. The device comprises a main section that removably attach to a handheld device around the perimeter thereof. The device further includes a first section opposite a second section, wherein each of the first and second sections folds and extends outward from the main section in a substantially wing-like fashion. Each of the first and second sections includes a plurality of control buttons for inputting commands to the handheld device. Embedded within the sections is a flex circuit that is configured to at least partially bend onto itself so as to manipulate the sections to and from an operating configuration and a storing configuration.

Abstract: Disclosed are a combination controller unit and a carrier device for handheld electronic devices. The device comprises a main section that removably attach to a handheld device around the perimeter thereof. The device further includes a first section opposite a second section, wherein each of the first and second sections folds and extends outward from the main section in a substantially wing-like fashion. Each of the first and second sections includes a plurality of control buttons for inputting commands to the handheld device. Embedded within the sections is a flex circuit that is configured to at least partially bend onto itself so as to manipulate the sections to and from an operating configuration and a storing configuration.

Abstract: An acetabular cup shell insertion system is provided for a shell having a threaded central opening and a part-spherical inner surface. The system includes an impactor having a strike plate at a first end and a first connection element at a second end. Also provided is a longitudinally extending adapter having a threaded first end adapted to threadably engage the threaded central opening in the acetabular cup. A second end of the adapter has a second connection element for engaging the impactor first connection element. An impaction flange extends radially outwardly of a longitudinal axis of the adapter. The flange has a first contact surface facing the second end of the adapter. A second contact surface surrounding the threaded first end of the adapter contacts the part-spherical inner surface of the acetabular cup surrounding the threaded central opening.

Abstract: An acetabular cup shell insertion system is provided for a shell having a threaded central opening and a part-spherical inner surface. The system includes an impactor having a strike plate at a first end and a first connection element at a second end. Also provided is a longitudinally extending adapter having a threaded first end adapted to threadably engage the threaded central opening in the acetabular cup. A second end of the adapter has a second connection element for engaging the impactor first connection element. An impaction flange extends radially outwardly of a longitudinal axis of the adapter. The flange has a first contact surface facing the second end of the adapter. A second contact surface surrounding the threaded first end of the adapter contacts the part-spherical inner surface of the acetabular cup surrounding the threaded central opening.

Abstract: Managing a physical resource is disclosed. Layout information that can be used to identify a location of a physical resource within an environment is received. Calendaring information associated with a reservation of the physical resource is received. Sensor information associated with one or more sensors monitoring the physical resource is received. The layout information, the calendar information, and the sensor information are used to manage scheduling of the physical resource.