Abstract: A hemostatic valve for sealing a medical device includes a unibody elongate member having a first end, a second end, and a central lumen extending therebetween, wherein the unibody elongate member is pliable. The hemostatic valve includes a reinforcement structure extending along at least a portion of the unibody elongate member, wherein the reinforcement structure is coupled to the unibody elongate member. An active tensioning mechanism including an actuator coupled to the unibody elongate member, wherein the actuator is moveable between (a) a first position wherein the central lumen is constricted and sealed, and (b) a second position wherein the central lumen is open, and wherein the tensioning mechanism includes at least one filament extending at least partially around the unibody elongate member. The hemostatic valve includes a biasing member configured to bias the actuator to the first position.