Patents by Inventor Brandon Guenthart

Brandon Guenthart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
    Patent number: 11968974
    Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: April 30, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Matthew Bacchetta, Scott Chicotka, Kenmond Fung, Brandon Guenthart, John O'Neill, Gordana Vunjak-Novakovic
  • Cell-seeded porous lung hydrogel sealant
    Patent number: 11291747
    Abstract: Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: April 5, 2022
    Assignee: The Trustees of Columbia University in The City of New York
    Inventors: Matthew Bacchetta, Brandon Guenthart, Jinho Kim, John O'Neill, Gordana Vunjak-Novakovic
  • CELL-SEEDED POROUS LUNG HYDROGEL SEALANT
    Publication number: 20190224364
    Abstract: Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 25, 2019
    Inventors: Matthew Bacchetta, Brandon Guenthart, Jinho Kim, John O'Neill, Gordana Vunjak-Novakovic
  • CROSS-CIRCULATION PLATFORM FOR RECOVERY, REGENERATION, AND MAINTENANCE OF EXTRACORPOREAL ORGANS
    Publication number: 20190141985
    Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
    Type: Application
    Filed: January 10, 2019
    Publication date: May 16, 2019
    Inventors: Matthew Bacchetta, Scott Chicotka, Kenmond Fung, Brandon Guenthart, John O'Neill, Gordana Vunjak-Novakovic