Patents by Inventor Brandon Heath Brown

Brandon Heath Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20220135527
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: January 19, 2022
    Publication date: May 5, 2022
    Inventors: Brandon Heath Brown, Troy Eva Reynolds
  • Processes for preparing ASK1 inhibitors
    Patent number: 11261161
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: March 1, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Brandon Heath Brown, Troy Evan Reynolds
  • Solid forms of a toll-like receptor modulator
    Patent number: 11072615
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 27, 2021
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon Heath Brown, Paul A. Roethle
  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20200283393
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: February 19, 2020
    Publication date: September 10, 2020
    Inventors: Brandon Heath Brown, Troy Evan Reynolds
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20200207771
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: November 8, 2019
    Publication date: July 2, 2020
    Inventors: Brandon Heath Brown, Yoo Joong Kim, Paul A. Roethle, Fang Wang
  • Processes for preparing ASK1 inhibitors
    Patent number: 10604490
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: March 31, 2020
    Assignee: Gilead Sciences, Inc.
    Inventors: Brandon Heath Brown, Troy Evan Reynolds
  • PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
    Publication number: 20190359644
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Application
    Filed: December 20, 2018
    Publication date: November 28, 2019
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • Solid forms of a toll-like receptor modulator
    Patent number: 10202384
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: February 12, 2019
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon Heath Brown, Yoo Joong Kim, Fang Wang
  • Processes and intermediates for preparing anti-HIV agents
    Patent number: 10196419
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 5, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
    Publication number: 20180079773
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 22, 2018
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20180022708
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: August 17, 2017
    Publication date: January 25, 2018
    Inventors: Brandon Heath Brown, Troy Reynolds
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20170313707
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 2, 2017
    Inventors: Patricia Andres, Brandon Heath Brown, Krista Marie Diaz, Yoo Joong Kim, Paul A. Roethle, Valeriya Smolenskaya, Fang Wang
  • Processes and intermediates for preparing anti-HIV agents
    Patent number: 9783567
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: October 10, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • Solid forms of a toll-like receptor modulator
    Patent number: 9738646
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: August 22, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon Heath Brown, Paul Roethle
  • PROCESSES FOR PREPARING ASK1 INHIBITORS
    Publication number: 20170233350
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: January 23, 2017
    Publication date: August 17, 2017
    Inventors: Brandon Heath Brown, Brenda J. Burke Chan, Anna Chiu, Nolan Griggs, Lars V. Heumann, Stephen P. Lathrop, Gregory Notte, Troy Evan Reynolds, Keshab Sarma, David Allen Siler, Andrew S. Thompson, Tao Wang
  • Methods of preparing toll-like receptor modulators
    Patent number: 9573952
    Abstract: The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 21, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Darin Allen, Brandon Heath Brown, Jessica Jade Chao, Randall L. Halcomb, Paul Hrvatin, Ryan McFadden, Paul Roethle, Erwina Rudio, Hong Yang, Richard Hung Chiu Yu
  • PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
    Publication number: 20160340379
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Application
    Filed: February 17, 2016
    Publication date: November 24, 2016
    Inventors: RICHARD HUNG CHIU YU, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • Processes for preparing ASK1 inhibitors
    Publication number: 20160244430
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Application
    Filed: December 22, 2015
    Publication date: August 25, 2016
    Applicant: Gilead Sciences, Inc.
    Inventors: Brandon Heath Brown, Brenda J. Burke Chan, Anna Chiu, Nolan Griggs, Lars V. Heumann, Stephen P. Lathrop, Troy Evan Reynolds, Keshab Sarma, David Allen Siler, Andrew S. Thompson, Tao Wang
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20160108045
    Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
    Type: Application
    Filed: September 14, 2015
    Publication date: April 21, 2016
    Inventors: Patricia Andres, Brandon Heath Brown, Krista Marie Diaz, Yoo Joong Kim, Paul Roethle, Fang Wang, Valeriya Smolenskaya
  • Processes and intermediates for preparing anti-HIV agents
    Patent number: 9296779
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: March 29, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Duc-Phi Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer