Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: In some aspects, the present disclosure pertains to self-expanding emboli-capturing centering devices for centering a medical instrument in a conduit within a patient. The centering devices comprise (a) an elongate shaft, (b) a self-expanding centering member having an open distal end and an inner surface forming a central lumen with a flared distal portion, the centering member being configured such that a fluid flowing in a distal-to-proximal direction that is received by the open distal end flows proximally along the flared distal portion of the central lumen before exiting the central lumen through one or more openings in a proximal portion of the centering member, and (c) a filter material configured to filter the fluid received by the open distal end of the centering member. Other aspects of the present disclosure pertain to systems and methods employing such centering devices.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: Magnetic vascular grafts and methods for their use are provided herein.

Abstract: Magnetic vascular grafts and methods for their use are provided herein.

Abstract: In some aspects, the present disclosure pertains to self-expanding emboli-capturing centering devices for centering a medical instrument in a conduit within a patient. The centering devices comprise (a) an elongate shaft, (b) a self-expanding centering member having an open distal end and an inner surface forming a central lumen with a flared distal portion, the centering member being configured such that a fluid flowing in a distal-to-proximal direction that is received by the open distal end flows proximally along the flared distal portion of the central lumen before exiting the central lumen through one or more openings in a proximal portion of the centering member, and (c) a filter material configured to filter the fluid received by the open distal end of the centering member. Other aspects of the present disclosure pertain to systems and methods employing such centering devices.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.

Abstract: Materials and methods for generating conformable stents at sites of stenosis in bodily vessels (e.g., blood vessels) are provided herein.

Abstract: An example medical device is disclosed. The device includes a tubular member having a lumen defined therein and a distal end portion, the distal end portion defining a guidewire port. The medical device also includes an expandable frame disposed along the distal end portion of the tubular member, the expandable frame being designed to shift between a first configuration and an expanded configuration. The frame includes a base, an end region and a plurality of struts extending between the base and the end region, the struts defining a plurality of apertures along the frame. The medical device also includes a cover attached to a portion of the frame and the cover is configured to cover one or more of the plurality of apertures such that the frame will align the guidewire port with an opening in a heart valve when the frame is positioned within a body lumen.

Abstract: Magnetic vascular grafts and methods for their use are provided herein.

Abstract: This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.