Abstract: Shipping system for temperature-sensitive materials. In one embodiment, the shipping system may include a frame defining an enclosure. The frame may include a bottom, a top, a front, a rear, a left side, a right side, a left corner gusset, and a right corner gusset. The front may serve as a door. Thermal breaks may be provided in one or more of the bottom, the front, the left corner gusset, and the right corner gusset. Vacuum insulated panels may be positioned along all sides of the frame. Many of the vacuum insulated panels may be encapsulated between the frame and an outer shell. A plurality of phase-change material assemblies may be positioned within the frame along all sides. Heat-spreaders may be positioned interior to the phase-change material assemblies. The shipping system may be dimensioned so that four such shipping systems may be seated on a prorate manual cargo sheet.