Patents by Inventor Brandon LaPorte

Brandon LaPorte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12318491
    Abstract: A device for delivery of a therapeutic agent to a surgical cavity, including: a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition including chitosan; a plurality of particles embedded within the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The first surface of the matrix is configured to be applied to the surgical cavity; the device releases the particles through the first surface; the device is also sterilized and provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity.
    Type: Grant
    Filed: December 15, 2023
    Date of Patent: June 3, 2025
    Assignee: PRIVO TECHNOLOGIES, INC.
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron M. Manzi, Amani Jahjaa
  • Publication number: 20250049725
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan. The composition may also include any or all of a hydration promotor, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles having an average diameter between 500 nm and 2000 nm are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Application
    Filed: July 24, 2024
    Publication date: February 13, 2025
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20250017869
    Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.
    Type: Application
    Filed: February 15, 2024
    Publication date: January 16, 2025
    Inventors: Manijeh Nazari Goldberg, Brandon Laporte, Aaron Nazari Manzi, Amritpreet Birdi
  • Publication number: 20240342109
    Abstract: A device for delivery of a therapeutic agent to a surgical cavity, including: a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition including chitosan; a plurality of particles embedded within the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The first surface of the matrix is configured to be applied to the surgical cavity; the device releases the particles through the first surface; the device is also sterilized and provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity.
    Type: Application
    Filed: December 15, 2023
    Publication date: October 17, 2024
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron M. Manzi, Amani Jahjaa
  • Patent number: 11938228
    Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: March 26, 2024
    Assignee: PRIVO TECHNOLOGIES, INC.
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amritpreet Birdi
  • Publication number: 20240041781
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan. The composition may also include any or all of a hydration promotor, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles having an average diameter between 500 nm and 2000 nm are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Application
    Filed: February 22, 2023
    Publication date: February 8, 2024
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Patent number: 11872319
    Abstract: A device for delivery of a therapeutic agent to a surgical cavity, including: a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition including chitosan; a plurality of particles embedded within the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The first surface of the matrix is configured to be applied to the surgical cavity; the device releases the particles through the first surface; the device is also sterilized and provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: January 16, 2024
    Assignee: PRIVO TECHNOLOGIES, INC.
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron M. Manzi, Amani Jahjaa
  • Patent number: 11617722
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan. The composition may also include any or all of a hydration promotor, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles having an average diameter between 500 nm and 2000 nm are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: April 4, 2023
    Assignee: PRIVO TECHNOLOGIES, INC.
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20200078315
    Abstract: A device for delivery of a therapeutic agent to a surgical cavity, including: a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition including chitosan; a plurality of particles embedded within the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The first surface of the matrix is configured to be applied to the surgical cavity; the device releases the particles through the first surface; the device is also sterilized and provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity.
    Type: Application
    Filed: November 11, 2019
    Publication date: March 12, 2020
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron M. Manzi, Amani Jahjaa
  • Publication number: 20190388356
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan. The composition may also include any or all of a hydration promotor, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles having an average diameter between 500 nm and 2000 nm are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 26, 2019
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Patent number: 10478403
    Abstract: A device for delivery of a therapeutic agent to a surgical cavity, including: a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition including chitosan; a plurality of particles embedded within the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan; and an additive selected from the group consisting of a hydration promoter, a particle adhesion inhibitor, a particle aggregation inhibitor, and combinations thereof. The first surface of the matrix is configured to be applied to the surgical cavity; the device releases the particles through the first surface; the device is also sterilized and provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: November 19, 2019
    Assignee: Privo Technologies, Inc.
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amani Jahjaa
  • Patent number: 10398655
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan, a hydration promoter, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 3, 2019
    Assignee: Privo Technologies, Inc.
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20190142760
    Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 16, 2019
    Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amritpreet Birdi
  • Patent number: 10159651
    Abstract: A method for manufacturing a therapeutic agent delivery system includes forming a first mixture with a plurality of microparticles, the microparticles containing a therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The method also includes forming a second mixture from ingredients including the first mixture, chitosan, a hydration promoter, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor, freezing the second mixture in a bath containing an aqueous alcoholic solution at a temperature above the freezing temperature of the aqueous alcoholic solution and at most ?40° C., to form a frozen layer precursor, and drying the frozen layer precursor to form a porous polymeric matrix with microparticles embedded within the matrix.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: December 25, 2018
    Assignee: Privo Technologies, Inc.
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20180235899
    Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.
    Type: Application
    Filed: February 16, 2018
    Publication date: August 23, 2018
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20180169025
    Abstract: A method for manufacturing a therapeutic agent delivery system includes forming a first mixture with a plurality of microparticles, the microparticles containing a therapeutic agent and having a coating around the therapeutic agent, the coating including chitosan. The method also includes forming a second mixture from ingredients including the first mixture, chitosan, a hydration promoter, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor, freezing the second mixture in a bath containing an aqueous alcoholic solution at a temperature above the freezing temperature of the aqueous alcoholic solution and at most ?40° C., to form a frozen layer precursor, and drying the frozen layer precursor to form a porous polymeric matrix with microparticles embedded within the matrix.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi
  • Publication number: 20170239189
    Abstract: A system for delivery of a therapeutic agent to a site in mucosal tissue is provided. The system includes a porous, mucoadhesive polymeric matrix having a first and a second opposed surfaces. The matrix is formed by a composition including chitosan, a hydration promoter, a microparticle adhesion inhibitor, and a microparticle aggregation inhibitor. A plurality of microparticles are embedded within the matrix. The microparticles contain a therapeutic agent and have a coating around the therapeutic agent. The first surface of the matrix is configured to be attached to the site in the mucosal tissue and the matrix is configured to provide controlled release of the microparticles through the first surface. The coating of the microparticles includes chitosan so as to provide controlled release of the agent from the microparticles.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 24, 2017
    Inventors: Manijeh Nazari Goldberg, Aaron Manzi, Brandon LaPorte, Amritpreet Birdi