Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, or autoimmune diseases.

Abstract: A system and method for using a fuel with an engine, an airframe having an aircraft heat load, a fuel tank, and a fuel oxygen reduction unit are provided. The method includes receiving an inlet fuel flow in the fuel oxygen reduction unit for reducing an amount of oxygen in the inlet fuel flow; separating a fuel/gas mixture within the fuel oxygen reduction unit into an outlet gas flow and an outlet fuel flow exiting the fuel oxygen reduction unit; controlling a first portion of the outlet fuel flow to the engine; and controlling a second portion of the outlet fuel flow to the airframe to transfer heat between the second portion of the outlet fuel flow and the aircraft heat load.

Abstract: Systems and other embodiments described herein relate to vehicle collision energy absorption with increased airflow towards an engine compartment of a vehicle. In one embodiment, the system includes a front energy absorber with a first top surface having an angle and a rear energy absorber with a second top surface that is curved. The rear energy absorber is separated from the front energy absorber by a gap and a plane of the first top surface is tangential to the second top surface.

Abstract: The present invention relates to the combination of certain flame retardant additives in a copolyester to improve the flame retardant properties of the copolyester composition while retaining thermal and impact properties, methods of making the copolyester composition and articles made from the copolyester composition. More specifically, the present invention relates to the use of brominated flame retardant compounds in copolyester compositions to improve the flame retardant properties while surprisingly retaining glass transition temperature and impact properties.

Abstract: A composition is provided comprising a cellulose ester component that comprises at least one cellulose ester; and an elastomeric component that comprises at least one elastomer, where the elastomeric component comprises 30 wt % or more of the composition, and where the composition is thermoplastic. Processes for producing the compositions as well as articles made using these compositions, such as automotive interior components, are also provided.

Abstract: Systems, methods, and computer-readable media are described for combining digital and analog beamsteering in a channelized antenna array. In some examples, a method can include receiving one or more signals at each of a plurality of groups of antenna elements, each group of antenna elements defining a respective channel from a plurality of channels, and steering, by each respective channel and using analog steering, the one or more signals in a respective direction to yield a steered analog signal pattern. The method can further include converting the steered analog signal pattern associated with each respective channel into a respective digital signal and, based on the respective digital signal, generating, using digital steering, digital signal patterns steered within the steered analog signal pattern associated with the respective digital signal.

Abstract: An optical fiber cable includes a jacket and a plurality of stranded core subunits, each core subunit comprising a flexible sheath and a plurality of ribbons arranged in a ribbon group, wherein each ribbon of the plurality of ribbons comprises a plurality of connected fibers such that 50-70% of the cross-sectional area inside the sheath is occupied by the connected fibers. The flexible sheath may be an extruded PVC material that conforms to the shape of the ribbon stack and keeps all of the ribbons acting as a unitary body during bending.

Abstract: Methods, apparatuses, and computer program products are disclosed for providing verified application access. An example method includes an access request for a first user device associated with a first user profile and determining an application associated with the access request. The example method further includes generating an evaluation element that includes testable content associated with the determined application and determining of the evaluation element by the first user device. In response to completion of the evaluation element by the first user device, the method includes providing access to the application for the first user device. The method also may include modifying the testable content of the evaluation element based upon one or more user parameters of the first user profile received from a user parameter database.

Abstract: Systems, methods, and computer-readable media are described for combining digital and analog beamsteering in a channelized antenna array. In some examples, a method can include receiving one or more signals at each of a plurality of groups of antenna elements, each group of antenna elements defining a respective channel from a plurality of channels, and steering, by each respective channel and using analog steering, the one or more signals in a respective direction to yield a steered analog signal pattern. The method can further include converting the steered analog signal pattern associated with each respective channel into a respective digital signal and, based on the respective digital signal, generating, using digital steering, digital signal patterns steered within the steered analog signal pattern associated with the respective digital signal.

Abstract: Methods, apparatuses, and computer program products are disclosed for providing verified application access. An example method includes an access request for a first user device associated with a first user profile and determining an application associated with the access request. The example method further includes generating an evaluation element that includes testable content associated with the determined application and determining of the evaluation element by the first user device. In response to completion of the evaluation element by the first user device, the method includes providing access to the application for the first user device. The method also may include modifying the testable content of the evaluation element based upon one or more user parameters of the first user profile received from a user parameter database.

Abstract: A radar system is generated by a process including generating a first substrate layer adjacent to a ground plane of a patch antenna array in the radar system, etching an opening in the substrate layer, inserting a mechanically-locking foot of a threaded insert into the opening, adding a second substrate layer adjacent to the first substrate layer to embed the threaded insert, applying a thermal coupling between a heat sink layer and the second substrate layer of the radar system and screwing a screw through the heat sink layer and into the threaded insert to adhere the heat sink layer to the radar system. Such a radar system can enable the attachment of the heat sink layer to the radar system in a removable fashion such that the heat sink layer can be removed by removing the screw and repairs can be done without damaging respective layers.

Abstract: Systems, methods, and computer-readable media are described for combining digital and analog beamsteering in a channelized antenna array. In some examples, a method can include receiving one or more signals at each of a plurality of groups of antenna elements, each group of antenna elements defining a respective channel from a plurality of channels, and steering, by each respective channel and using analog steering, the one or more signals in a respective direction to yield a steered analog signal pattern. The method can further include converting the steered analog signal pattern associated with each respective channel into a respective digital signal and, based on the respective digital signal, generating, using digital steering, digital signal patterns steered within the steered analog signal pattern associated with the respective digital signal.

Abstract: A device provisioning configuration request from a network device to be configured is received. The network device provides the request to a network location obtained via a Dynamic Host Configuration Protocol request made automatically by the network device. A configuration agent script is provided in response to the device provisioning configuration request. One or more notifications associated with a provisioning progress are received from the network device via the configuration agent script. At least one of the one or more notifications is utilized in a provisioning workflow.

Abstract: An optical fiber cable includes a jacket and a plurality of stranded core subunits, each core subunit comprising a flexible sheath and a plurality of ribbons arranged in a ribbon group, wherein each ribbon of the plurality of ribbons comprises a plurality of connected fibers such that 50-70% of the cross-sectional area inside the sheath is occupied by the connected fibers. The flexible sheath may be an extruded PVC material that conforms to the shape of the ribbon stack and keeps all of the ribbons acting as a unitary body during bending.

Abstract: A computer-implemented technique is described herein for extracting facts from unstructured text documents provided by one or more information sources. The technique uses a pipeline to perform this operation that involves, at least in part, providing a corpus of information items, extracting candidate facts from the information items, merging synonymous argument values associated with the candidate facts, organizing the candidate facts into relation clusters, and assessing the confidence level of the candidate facts within the relation clusters.

Abstract: An optical fiber cable includes a jacket and a plurality of stranded core subunits, each core subunit comprising a flexible sheath and a plurality of ribbons arranged in a ribbon group, wherein each ribbon of the plurality of ribbons comprises a plurality of connected fibers such that 50-70% of the cross-sectional area inside the sheath is occupied by the connected fibers. The flexible sheath may be an extruded PVC material that conforms to the shape of the ribbon stack and keeps all of the ribbons acting as a unitary body during bending.

Abstract: A unique method provides real estate mortgage and investment analyses to a user. The method is implemented through a mortgage analyzer that comprises an add-on extension to an Internet browsing client. The method facilitates analyses for prospective real estate properties with various input data and allows easy sharing of analysis results with others. The method offers mortgage scenario comparison and investment option analysis that provide not only the optimal mortgage choice, but also the most promising investment opportunity. Additionally, the method scrapes information directly off property listing webpages viewed by the user, eliminating the need for manual input of information the user is already viewing. Further, the method allows the user to initiate a mortgage loan application directly to a desired mortgage lender entity. Thus, the present invention provides a versatile and powerful method to the user to make optimal decisions for real estate mortgage borrowing and investment opportunities.